Wong C L, Bentley G A
Eur J Pharmacol. 1979 Feb 1;53(4):391-4. doi: 10.1016/0014-2999(79)90466-7.
Morphine caused an apparently dose-dependent hypothermia in mice. Co-administration of naloxone antagonised this effect. Pretreatment with a single dose of morphine induced detectable tolerance to the hypothermic effect of a second dose of morphine given 3 h later and naloxone was more effective in antagonising the hypothermic effect of morphine in morphine-pretreated mice than in saline-pretreated animals. The present study has shown that morphine pretreatment can augment the antagonistic effect of naloxone towards the hypothermic action of morphine.
吗啡可使小鼠出现明显的剂量依赖性体温过低。联合使用纳洛酮可拮抗此效应。单次注射吗啡进行预处理可诱导对3小时后给予的第二剂吗啡的体温过低效应产生可检测到的耐受性，并且与生理盐水预处理的动物相比，纳洛酮在拮抗吗啡预处理小鼠中吗啡的体温过低效应方面更有效。本研究表明，吗啡预处理可增强纳洛酮对吗啡体温过低作用的拮抗效应。
