连锁不平衡的方向。
The direction of linkage disequilibrium.
作者信息
Langley C H, Crow J F
出版信息
Genetics. 1974 Nov;78(3):937-41. doi: 10.1093/genetics/78.3.937.
Abstract
The previous paper (Langley, Tobari and Kojima 1974) reports that the directional linkage disequilibria, D(omega) = P(AB)P(ab)-P(Ab)P(aB), tend to be negative for data between allozymes and linked to inversions. A and B stand for the two alleles with the greatest frequency in the population. In this paper we show that linkage disequilibrium in this direction is produced at equilibrium when double homozygotes have fitnesses that are a constant fraction of the product of the two component single homozygote fitnesses, a pattern that is frequently observed in experimental data.
摘要
上一篇论文（兰利、托巴里和小岛，1974年）报道，方向连锁不平衡D(ω)=P(AB)P(ab)-P(Ab)P(aB)，对于等位酶之间的数据往往为负，且与倒位相关。A和B代表群体中频率最高的两个等位基因。在本文中，我们表明，当双纯合子的适合度是两个组成单纯合子适合度乘积的一个恒定分数时，在平衡状态下会产生这种方向的连锁不平衡，这种模式在实验数据中经常观察到。
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