The pre-albumin fraction: a useful parameter in the interpretation of routine protein electrophoresis.

A technique of protein electrophoresis suitable for routine use which ensures good separation of the prealbumin fraction is described. The clinical value of visually estimating this protein fraction from the electrophoretic strip is shown with reference to 134 cases. Low levels of prealbumin were found to be associated with liver disorders, malignancy, collagen diseases, congestive cardiac failure, and burns. Finally, pitfalls in electrophoretic technique which may cause failure to visualize the prealbumin fraction are discussed.