[托米嗪骨髓毒性作用的实验研究]
[Experimental study of the myelotoxic effect of tomizine].
作者信息
Gol'dberg E D, Novitskiĭ V V, Plotnikov V M, Dalinger L M, Chernov V A
出版信息
Farmakol Toksikol. 1979 Jan-Feb;42(1):85-9.
In tests conducted on 220 rats with transplantable sarcoma M-1 and intact animals acute toxicity, antineoplastic effect and the action on the blood system of tomizine, a new neoplastic drug of the group of the folic acid antagonists, were studied. Investigation involved a single intraperitoneal injection of the drug in DL50/30 and MTD. The compound is shown to exert an inhibiting action on the development of sarcoma M-1 and lengthens the survival of the tumour-stricken animals, without producing any pronounced myelotoxic effect. The disclosed shifts on the level of the periphedal blood and marrow were short-lived and concerned mainly the erythroid germ cells.
在对220只患有可移植性肉瘤M-1的大鼠以及健康动物进行的试验中，研究了一种新型叶酸拮抗剂类抗肿瘤药物托米嗪的急性毒性、抗肿瘤作用及其对血液系统的影响。研究包括以半数致死剂量的30%（DL50/30）和最大耐受剂量（MTD）对药物进行单次腹腔注射。结果表明，该化合物对肉瘤M-1的发展具有抑制作用，并延长了患瘤动物的存活时间，且未产生任何明显的骨髓毒性作用。在外周血和骨髓水平上所发现的变化是短暂的，主要涉及红系生殖细胞。
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