Strum J M, Becci P J
Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 Oct;31(2):135-42. doi: 10.1007/BF02889931.
The purpose of this study was to determine whether or not endogenous mammary peroxidase can serve as a cytochemical marker to distinguish ovarian hormone-dependent from ovarian hormone independent mammary tumors. Spontaneous mammary tumors arising in virgin C3H and GR mice (hormone independent tumors) and hormone-dependent mammary tumors arising during pregnancy in GR mice were examined. None of these tumors contained mammary peroxidase. Mammary tumors induced in Sprague-Dawley rats with methylnitrousourea (MNU) and dimethylbenzanthracene (DMBA) were also examined. These tumors included hormone-dependent and hormone independent ones. Several of the DMBA-induced hormone-dependent tumors contained a few peroxidase-positive cells, but the hormone independent tumors were negative. All of the MNU-induced tumors examined were negative for mammary peroxidase. Twenty human breast tumors (malignant and non-malignant) removed from women at surgery, were also negative for mammary peroxidase. Our results indicate that endogenous mammary peroxidase cannot be used to distinguish hormone-dependent from hormone independent mammary tumors.
本研究的目的是确定内源性乳腺过氧化物酶是否可作为一种细胞化学标志物，用于区分卵巢激素依赖性和非依赖性乳腺肿瘤。对处女C3H和GR小鼠中自发产生的乳腺肿瘤（激素非依赖性肿瘤）以及GR小鼠孕期产生的激素依赖性乳腺肿瘤进行了检查。这些肿瘤均未含有乳腺过氧化物酶。还对用甲基亚硝基脲（MNU）和二甲基苯并蒽（DMBA）诱导的斯普拉格-道利大鼠乳腺肿瘤进行了检查。这些肿瘤包括激素依赖性和非依赖性肿瘤。一些DMBA诱导的激素依赖性肿瘤含有少量过氧化物酶阳性细胞，但激素非依赖性肿瘤为阴性。所有检查的MNU诱导肿瘤的乳腺过氧化物酶均为阴性。从手术女性身上切除的20例人类乳腺肿瘤（恶性和非恶性）的乳腺过氧化物酶也为阴性。我们的结果表明，内源性乳腺过氧化物酶不能用于区分激素依赖性和非依赖性乳腺肿瘤。
