Levy J, Liel Y, Glick S M
Isr J Med Sci. 1981 Sep-Oct;17(9-10):970-5.
We examined the possibility that peroxidase activity might be a marker for estrogen activity in established estrogen-dependent tissues: dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumors and human breast cancer. In DMBA-induced tumors undergoing regression after ovariectomy or tamoxifen treatment, tumor size decreased by 50%, estradiol receptors (ER) and progesterone receptors (PgR) decreased by 25 and 20%, respectively, but peroxidase activity paradoxically increased six- to sevenfold. In DMBA tumors stimulated by estradiol treatment or by the cessation of tamoxifen administration in intact rats, tumor size increased threefold. ER and PgR increased two- and threefold, respectively, while peroxidase activity decreased 50%. These data indicate an inverse relation between tumor growth, ER and PgR on the one hand, and peroxidase activity on the other. In the human breast cancers there was a significant negative relation between the presence of ER and peroxidase activity. By using a calibrated Sephadex G-100 column it was shown that uterine peroxidase differs in molecular weight from the peroxidase of rat mammary tumors and that of human breast cancer.
二甲基苯并[a]蒽（DMBA）诱导的大鼠乳腺肿瘤和人类乳腺癌。在卵巢切除或他莫昔芬治疗后正在消退的DMBA诱导的肿瘤中，肿瘤大小减少了50%，雌二醇受体（ER）和孕酮受体（PgR）分别减少了25%和20%，但过氧化物酶活性却反常地增加了6至7倍。在完整大鼠中，经雌二醇治疗或停止给予他莫昔芬刺激的DMBA肿瘤中，肿瘤大小增加了三倍。ER和PgR分别增加了两倍和三倍，而过氧化物酶活性降低了50%。这些数据表明，一方面肿瘤生长、ER和PgR与另一方面过氧化物酶活性之间存在反比关系。在人类乳腺癌中，ER的存在与过氧化物酶活性之间存在显著的负相关。通过使用校准的Sephadex G - 100柱表明，子宫过氧化物酶的分子量与大鼠乳腺肿瘤和人类乳腺癌的过氧化物酶不同。
