[使用左旋咪唑治疗复发性单纯疱疹]
[Management of recurrent herpes simplex using levamisole].
作者信息
Luderschmidt C, Wolff H H
出版信息
Hautarzt. 1979 Jan;30(1):21-4.
The therapeutic effect of levamisole was tested in a double blind and open clinical study in 30 patients with recurrent labial and genital herpes simplex. The frequency, the duration and the painfulness of the herpes eruptions were improved significantly under levamisole treatment. Agranulocytosis is an important adverse reaction which restricts the practical use of the substance. The increase of phagocytosis of granulocytes and macrophages and the normalization of defective cell mediated immune reactions are the supposed mechanisms of levamisole action.
在一项针对30例复发性唇和生殖器单纯疱疹患者的双盲和开放临床研究中，对左旋咪唑的治疗效果进行了测试。在左旋咪唑治疗下，疱疹发作的频率、持续时间和疼痛程度均有显著改善。粒细胞缺乏症是一种重要的不良反应，限制了该药物的实际应用。粒细胞和巨噬细胞吞噬作用的增强以及缺陷性细胞介导免疫反应的正常化被认为是左旋咪唑作用的机制。
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