Kohler E M, Bohl E H
Can J Comp Med Vet Sci. 1966 Jul;30(7):199-203.
The successful experimental production of colibacillosis in young gnotobiotic pigs by the oral administration of E. COLI (08:K.:H21 was accomplished. Colibacillosis was not produced in gnotobiotic pigs infected with either of the 2 other strains of E.COLI employed.Necropsy observations were presented and discussed. Emphasis was placed on the absence of grossly visible enteritis in pigs that died in the acute phase of the disease. The gross appearance of the intestinal tract changed some hours after death to resemble that associated with enteritis.Bacteremia was detected in the gnotobiotic pigs orally infected with each of the 3 strains of E. COLI, and the special characteristics of the colostrum-deprived pig were stressed as important factors in these findings.
通过口服大肠杆菌（08:K.:H21）成功地在无菌仔猪中实验性诱发了大肠杆菌病。用另外两种所使用的大肠杆菌菌株感染无菌仔猪时，未诱发大肠杆菌病。对尸检结果进行了展示和讨论。重点强调了在疾病急性期死亡的猪中未出现肉眼可见的肠炎。死后数小时肠道的外观发生变化，类似于与肠炎相关的外观。在口服感染三种大肠杆菌菌株的无菌仔猪中均检测到菌血症，并且强调了初乳缺乏仔猪的特殊特征是这些结果中的重要因素。
