Corrêa W M, Nilsson M R
Can J Comp Med Vet Sci. 1966 Apr;30(4):112-6.
Five livers of equine fetuses, aborted due to the action of equine abortion virus, five livers from men, two of whom died of epidemic hepatitis and three obtained by needle biopsies, 5 livers of dogs with infectious canine hepatitis and 7 livers of ducklings that had hepatitis, were studied histopathologically. The foals' livers were studied by several staining methods and the others by H. E. only. The results indicate that the lesions are quite similar in the four species with the appearance of nuclear inclusion bodies only in foals and dogs. The strong staining properties of the nuclear inclusion bodies in infectious canine hepatitis and the weak staining properties of the equine virus abortion reveal that the protein-DNA association is different resulting in a different electropolarity. The lesions in foals are of two main types, one a Necrotic-Mosaic Type in which the hepatocyte degeneration is irregularly distributed within the hepatic lobules and the other an Hyperplastic Type in which marked regeneration occurs. In the Hyperplastic Type the practical absence of plasmocytes in foals' livers might suggest that if the newborn is a female, abortions may occur later in life because the virus remained alive in colts which were born in an immune tolerance state.Histologically the picture in the livers of aborted foals assume features of a viral hepatitis similar to the viral hepatitis in men, dogs and ducklings.
对5例因马流产病毒作用而流产的马胎儿肝脏、5例男性肝脏（其中2例死于暴发性肝炎，3例通过针吸活检获得）、5例患有犬传染性肝炎的犬肝脏以及7例患有肝炎的雏鸭肝脏进行了组织病理学研究。马驹的肝脏采用多种染色方法进行研究，其他肝脏仅采用苏木精-伊红染色法。结果表明，这四个物种的病变非常相似，仅在马驹和犬中出现核内包涵体。犬传染性肝炎中核内包涵体的强染色特性与马病毒性流产中核内包涵体的弱染色特性表明，蛋白质-DNA结合不同，导致电极性不同。马驹的病变主要有两种类型，一种是坏死-镶嵌型，其中肝细胞变性在肝小叶内分布不规则，另一种是增生型，其中发生明显的再生。在增生型中，马驹肝脏中几乎没有浆细胞，这可能表明，如果新生马驹是雌性，以后可能会发生流产，因为病毒在处于免疫耐受状态下出生的雄驹体内仍然存活。组织学上，流产马驹肝脏的表现具有病毒性肝炎的特征，类似于人类、犬和雏鸭的病毒性肝炎。
