关于经由犬尿氨酸的色氨酸代谢调控
On the regulation of tryptophan metabolism "via" kynurenine.
作者信息
Shibata Y
出版信息
Acta Vitaminol Enzymol. 1978;32(5-6):195-207.
PMID:42292
Abstract
The tryptophan leads to nicotinic acid pathway is inhibited in the nicotinic acid administered rats; in this case tryptophan chiefly metabolizes "via" serotonin. The serotonin pathway is inhibited in the excess phenylalanine administered rats, especially due to the inhibition of the tryptophan-5-hydroxylase reaction. Xanthurenic acid inhibits kynurenine-3-hydroxylase in vitro, which is a very important regulatory enzyme for xanthurenic acid and nicotinic acid production.
摘要
在给予烟酸的大鼠中，色氨酸转化为烟酸的途径受到抑制；在这种情况下，色氨酸主要通过血清素进行代谢。在给予过量苯丙氨酸的大鼠中，血清素途径受到抑制，尤其是由于色氨酸-5-羟化酶反应受到抑制。黄尿酸在体外抑制犬尿氨酸-3-羟化酶，该酶是黄尿酸和烟酸生成的非常重要的调节酶。
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引用本文的文献
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Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection.色氨酸注射后维生素B6缺乏大鼠肝脏中的犬尿氨酸代谢
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