Kurbanov Kh, Berezov T T
Vopr Med Khim. 1976 Sep-Oct;22(5):683-7.
An activity of tryptophan pyrrolase was not observed in skin of healthy persons and of patients with vitiligo. Content of serotonin was similar in skin of normal persons and in skin of patients with normal pigmentation and in depigmented area. But content of serotonin in blood and excretion of anthranilic acid were decreased in the patients as compared with healthy persons. Excretion of kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, kynureninic, xanthurenic and 5-hydroxyindolyl acetic acids was increased in patients and this increase was more distinct after loading with 1-tryptophan. The data obtained suggest that kynurenine and serotonin pathways of tryptophan metabolism were intensified in vitiligo.
在健康人和白癜风患者的皮肤中均未观察到色氨酸吡咯酶的活性。正常人的皮肤、色素正常患者的皮肤以及色素脱失区域的皮肤中血清素含量相似。但与健康人相比，患者血液中的血清素含量和邻氨基苯甲酸的排泄量降低。患者中犬尿氨酸、3-羟基犬尿氨酸、3-羟基邻氨基苯甲酸、犬尿酸、黄尿酸和5-羟基吲哚乙酸的排泄量增加，且在给予1-色氨酸负荷后这种增加更为明显。所得数据表明，白癜风患者色氨酸代谢的犬尿氨酸和血清素途径增强。
