Hayward M, Seaton D
J Neurol Neurosurg Psychiatry. 1979 Feb;42(2):117-22. doi: 10.1136/jnnp.42.2.117.
A prospective study was carried out on 24 volunteers who had suffered from paralytic poliomyelitis up to 51 years earlier. A quantitative EMG was carried out in each subject. Grossly raised mean amplitudes of the interference patterns were found in many strong muscles as well as in weak muscles. Such muscles frequently showed "contraction fasciculation", a manifestation of loss of normal small motor units. In many subjects the clinical and EMG evidence of chronic partial denervation were more widespread than the subjects had realised. It is suggested that if, with advancing age, minor damage occurs to the peripheral nervous system and the complement of motor neurones is already depleted by poliomyelitis, there will be an exaggerated response with increase in the lower motor neurone signs.
对24名在51年前曾患过麻痹性脊髓灰质炎的志愿者进行了一项前瞻性研究。对每名受试者进行了定量肌电图检查。在许多强壮肌肉以及虚弱肌肉中均发现干扰型平均波幅明显升高。此类肌肉经常出现“收缩性肌束震颤”，这是正常小运动单位丧失的一种表现。在许多受试者中，慢性部分失神经的临床和肌电图证据比受试者所意识到的更为广泛。有人提出，如果随着年龄增长，外周神经系统发生轻微损伤，而运动神经元的数量已因脊髓灰质炎而减少，那么下运动神经元体征将会出现夸张的反应并增多。
