Williams A, Hanson D, Calne D B
J Neurol Neurosurg Psychiatry. 1979 Feb;42(2):151-3. doi: 10.1136/jnnp.42.2.151.
Eight out of 12 unselected patients with Shy-Drager syndrome were found to have severe bilateral paresis of vocal cord abduction by fibre-optic laryngoscopy. This commonly presented as increased snoring followed by episodes of inspiratory and expiratory stridor and sometimes by sleep apnoea. Respiratory failure eventually developed in four cases and was reversed by tracheostomy. In another patient tracheostomy relieved severe attacks of sleep apnoea. This complication was not necessarily associated with advanced disease, and it should be considered in all patients with Shy-Drager syndrome as appropriate treatment can lead to a useful extension of life.
在12例未经挑选的Shy-Drager综合征患者中,经纤维喉镜检查发现,有8例存在严重的双侧声带外展麻痹。这通常表现为打鼾加重,随后出现吸气性和呼气性喘鸣发作,有时还伴有睡眠呼吸暂停。最终有4例患者发展为呼吸衰竭,而行气管切开术后呼吸衰竭得以缓解。另有1例患者,气管切开术缓解了严重的睡眠呼吸暂停发作。这种并发症不一定与疾病晚期相关,对于所有Shy-Drager综合征患者都应予以考虑,因为适当的治疗可有效延长生命。