Maronpot R R, Whitehair C K
Can J Comp Med Vet Sci. 1967 Dec;31(12):309-16.
The virus of transmissible gastroenteritis produced sprue-like lesions in the small intestines of young pigs. These lesions were characterized by villous shortening, fusing and blunting in the jejunum and ileum. There was decreased height of the brush border and morphologic alteration of the villous epithelial cells from simple columnar to a variable cuboidal type. Accompanying these microscopic lesions were histochemical changes characterized by decreased staining intensity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, leucine aminopeptidase, succinic dehydrogenase and malic dehydrogenase in the affected intestinal mucosa. The clinical nature of transmissible gastroenteritis in the pig together with the histopathologic and histochemical changes may provide a useful experimental model for obtaining additional basic information on enteric disturbances.
传染性胃肠炎病毒在幼猪小肠内产生了口炎性腹泻样病变。这些病变的特征是空肠和回肠绒毛缩短、融合及变钝。刷状缘高度降低，绒毛上皮细胞形态从简单的柱状变为可变的立方体型。伴随这些微观病变的是组织化学变化，其特征是受影响的肠黏膜中酸性磷酸酶、碱性磷酸酶、三磷酸腺苷酶、亮氨酸氨肽酶、琥珀酸脱氢酶和苹果酸脱氢酶的染色强度降低。猪传染性胃肠炎的临床特征以及组织病理学和组织化学变化可能为获取有关肠道紊乱的更多基础信息提供一个有用的实验模型。
