Drolet R, Morin M, Fontaine M
Can J Comp Med. 1984 Jul;48(3):282-5.
The main purpose of this work was to study changes in the balance of fluids, electrolytes and blood metabolites in neonatal piglets with severe transmissible gastroenteritis. Six two day old conventional piglets were infected with transmissible gastroenteritis virus while six others were used as normal controls. Blood samples were collected in heparin when the infected piglets were moribund. The following variables were measured: packed red cell volume, total plasma protein and bicarbonate, blood pH, blood urea nitrogen and plasma glucose, creatinine, chloride, inorganic phosphorus, sodium, potassium, magnesium and calcium. Vomiting and diarrhea appeared 12 to 24 hours postinoculation in the infected piglets and they were moribund one or two days later. Before becoming moribund, most of the piglets fell rapidly into a lethargic and comatose state. The most evident changes in their blood variables were an increase in packed cell volume, total protein, blood urea nitrogen, phosphorus and magnesium levels and a decrease in pH and bicarbonate concentration as well as a severe hypoglycemia. The results suggest that severe hypoglycemia coupled with metabolic acidosis and dehydration might be an important factor contributing to the high mortality rates caused by transmissible gastroenteritis in neonatal piglets. The hypoglycemia results from a combination of the inadequate glucose metabolism inherent to neonatal piglets and the acute maldigestion and malabsorption resulting from the diffuse and severe villous atrophy induced by the virus.
这项工作的主要目的是研究患有严重传染性胃肠炎的新生仔猪的体液、电解质和血液代谢物平衡的变化。六只两日龄的普通仔猪感染了传染性胃肠炎病毒，另外六只作为正常对照。当感染的仔猪濒死时，采集肝素化血液样本。测量了以下变量：红细胞压积、总血浆蛋白和碳酸氢盐、血液pH值、血尿素氮和血浆葡萄糖、肌酐、氯、无机磷、钠、钾、镁和钙。感染的仔猪在接种后12至24小时出现呕吐和腹泻，一或两天后濒死。在濒死之前，大多数仔猪迅速陷入嗜睡和昏迷状态。它们血液变量中最明显的变化是红细胞压积、总蛋白、血尿素氮、磷和镁水平升高，pH值和碳酸氢盐浓度降低以及严重低血糖。结果表明，严重低血糖伴代谢性酸中毒和脱水可能是导致新生仔猪传染性胃肠炎高死亡率的一个重要因素。低血糖是新生仔猪固有的葡萄糖代谢不足与病毒引起的弥漫性严重绒毛萎缩导致的急性消化和吸收不良共同作用的结果。
