Laws E R, Piepgras D G, Randall R V, Abboud C F
J Neurosurg. 1979 Apr;50(4):454-61. doi: 10.3171/jns.1979.50.4.0454.
A consecutive series of 82 acromegalic patients who underwent transsphenoidal surgery during a 5-year period is presented. Preoperative and postoperative values for human growth hormone (HGH) were available in 80 cases. Microadenomas were present in 18 patients with a mean preoperative HGH value of 25.2 ng/ml, diffuse adenomas in 39 patients with mean of 53.8 ng/ml, and invasive adenomas in 25 with mean of 68.0 ng/ml. There was no operative mortality. The results reflected the classification of the tumors, with apparent cures accomplished in 87.5% of previously untreated patients with microadenoma, all of whom had anterior pituitary function preserved. The percentages of apparent cures in cases of diffuse adenoma (68%) and invasive adenoma (54%) were much less satisfactory. Transsphenoidal microsurgery is capable of achieving good results, particularly in patients with microadenoma.
本文报告了在5年期间接受经蝶窦手术的82例肢端肥大症患者的连续病例系列。80例患者有术前和术后人生长激素（HGH）值。18例患者为微腺瘤，术前HGH平均 值为25.2 ng/ml；39例为弥漫性腺瘤，平均值为53.8 ng/ml；25例为侵袭性腺瘤，平均值为68.0 ng/ml。无手术死亡病例。结果反映了肿瘤的分类情况，87.5%先前未经治疗的微腺瘤患者实现了明显治愈，所有这些患者的垂体前叶功能均得以保留。弥漫性腺瘤（68%）和侵袭性腺瘤（54%）的明显治愈百分比则远不如人意。经蝶窦显微手术能够取得良好效果，尤其是对于微腺瘤患者。
