Verrusio A C, Pollard D R, Fraser F C
Science. 1968 Apr 12;160(3824):206-7. doi: 10.1126/science.160.3824.206.
The frequency of congenital cleft palate produced by maternal treatment with 6-aminonicotinamide during pregnancy is lower in the C57BL/6J than in the A/J inbred mouse strain. In the C57BL/6J strain the frequency is lower when the mothers are maintained on Purina Lab Chow than when they are on Breeder Chow. A/J females do not show this effect of diet. There is a matroclinous reciprocal cross difference in frequency of induced cleft palate which persists in the back-cross when the F(1) mothers are maintained on Lab Chow but not on Breeder Chow.
孕期用6-氨基烟酰胺处理母鼠所产生的先天性腭裂频率，在C57BL/6J近交系小鼠中低于A/J近交系小鼠。在C57BL/6J品系中，当母鼠食用普瑞纳实验室饲料时，先天性腭裂的频率低于食用繁殖用饲料时。A/J雌鼠未表现出这种饮食效应。诱导性腭裂频率存在母性遗传的正反交差异，当F(1)代母鼠食用实验室饲料而非繁殖用饲料时，这种差异在回交中依然存在。
