犬体内氯解磷定的吸收与消除动力学
Kinetics of absorption and elimination of pralidoxime chloride in dogs.
作者信息
Lemanowicz E F, Sugita E T, Niebergall P J, Schnaare R L
出版信息
J Pharm Sci. 1979 Feb;68(2):141-5. doi: 10.1002/jps.2600680206.
PMID:423079
Abstract
The kinetics of the absorption and elimination of pralidoxime chloride were investigated in the dog. Similar apparent elimination rate constants were obtained after intravenous, intramuscular, and oral administration. Although oral absorption occurred slowly, intramuscular absorption proceeded rapidly. With in situ techniques, it was found that no absorption occurred from the isolated stomach and duodenum but that absorption did take place from the jejunum and ileum.
摘要
在犬体内研究了氯解磷定的吸收和消除动力学。静脉注射、肌肉注射和口服给药后获得了相似的表观消除速率常数。虽然口服吸收缓慢，但肌肉注射吸收迅速。采用原位技术发现，氯解磷定在离体胃和十二指肠不吸收，但在空肠和回肠可以吸收。
相似文献
1
Kinetics of absorption and elimination of pralidoxime chloride in dogs.犬体内氯解磷定的吸收与消除动力学
J Pharm Sci. 1979 Feb;68(2):141-5. doi: 10.1002/jps.2600680206.
2
Pralidoxime mesylate absorption and heart rate response to atropine sulphate following intramuscular administration of solution mixtures.肌肉注射溶液混合物后，甲磺磷解磷定的吸收及对硫酸阿托品的心率反应。
Br J Clin Pharmacol. 1975 Aug;2(4):333-8. doi: 10.1111/j.1365-2125.1975.tb02780.x.
3
Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.
J Med Chem. 1976 Jan;19(1):108-12. doi: 10.1021/jm00223a018.
4
Toxogonin and pralidoxime: kinetic comparison after intravenous administration to man.氯磷定和碘解磷定：静脉注射给人后的动力学比较。
J Pharm Sci. 1972 Nov;61(11):1765-9. doi: 10.1002/jps.2600611115.
5
6
Intramuscular and intravenous administration of small doses of 2-pyridinium aldoxime methochloride to man.向人体肌肉注射和静脉注射小剂量的氯解磷定。
J Pharm Sci. 1971 Aug;60(8):1224-8. doi: 10.1002/jps.2600600823.
7
Studies on the increased absorption of ouabain, phenolsulphonphthalein and pralidoxime caused by sodium lauryl sulphate from single loop preparations in the rat.关于十二烷基硫酸钠导致大鼠单环制剂中哇巴因、酚磺酞和氯解磷定吸收增加的研究。
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(1):45-57. doi: 10.1007/BF00647402.
8
Therapeutic dosing of pralidoxime chloride.
Drug Intell Clin Pharm. 1987 Jul-Aug;21(7-8):590-3. doi: 10.1177/1060028087021007-804.
9
Effect of intravenous thiamine on pralidoxime kinetics.静脉注射硫胺素对氯解磷定动力学的影响。
Clin Pharmacol Ther. 1978 Jul;24(1):95-100. doi: 10.1002/cpt197824195.
10
Intestinal absorption of pralidoxime and other aldoximes.解磷定及其他醛肟类药物的肠道吸收
Nature. 1966 Jan 15;209(5020):269-71. doi: 10.1038/209269a0.
Zotero 插件