Lemanowicz E F, Sugita E T, Niebergall P J, Schnaare R L
J Pharm Sci. 1979 Feb;68(2):141-5. doi: 10.1002/jps.2600680206.
The kinetics of the absorption and elimination of pralidoxime chloride were investigated in the dog. Similar apparent elimination rate constants were obtained after intravenous, intramuscular, and oral administration. Although oral absorption occurred slowly, intramuscular absorption proceeded rapidly. With in situ techniques, it was found that no absorption occurred from the isolated stomach and duodenum but that absorption did take place from the jejunum and ileum.
在犬体内研究了氯解磷定的吸收和消除动力学。静脉注射、肌肉注射和口服给药后获得了相似的表观消除速率常数。虽然口服吸收缓慢，但肌肉注射吸收迅速。采用原位技术发现，氯解磷定在离体胃和十二指肠不吸收，但在空肠和回肠可以吸收。
