Enever R P, Li Wan Po A, Shotton E
J Pharm Sci. 1979 Feb;68(2):169-71. doi: 10.1002/jps.2600680212.
Flupenthixol dihydrochloride in aqueous solution oxidized to trifluoromethylthioxanthone, ethanol, and piperazine via aldehydic and epoxidic intermediates in the presence of air. The formation rate of trifluoromethylthioxanthone increased with increases in pH and oxygen concentration. Buffer ions also affected the decomposition rate. Micelle formation by the drug markedly influenced its oxidation rate.
在空气中，盐酸氟哌噻吨在水溶液中通过醛和环氧中间体氧化为三氟甲基硫杂蒽酮、乙醇和哌嗪。三氟甲基硫杂蒽酮的形成速率随着pH值和氧浓度的增加而增加。缓冲离子也影响分解速率。该药物形成胶束显著影响其氧化速率。
