Nasir S S, Wilken L O, Nasir S M
J Pharm Sci. 1979 Feb;68(2):177-81. doi: 10.1002/jps.2600680215.
A new in vitro dissolution test apparatus was designed and evaluated. Compressed tablets of drugs representing different solubility characteristics were tested at various air pressures and compared to dissolution patterns of similar tablets by the Levy beaker and USP methods. Air pressure of 46 mm generally was suitable for determining the dissolution rates of tablets. This new dissolution tester possibly can be useful in determining drug release from solid dosage forms and correlating it with in vivo bioavailability because dissolution rate can be controlled easily with the adjustment of air pressure without complicated changes in the apparatus, there is no excessive settling of particles, and complete drug dissolution can be achieved with no clogging of the screen.
设计并评估了一种新型体外溶出度测试装置。对代表不同溶解度特征的药物压制片在不同气压下进行测试，并与采用Levy烧杯法和美国药典方法测试的类似片剂的溶出模式进行比较。46毫米汞柱的气压通常适用于测定片剂的溶出速率。这种新型溶出度测试仪可能有助于确定固体剂型中药物的释放情况，并将其与体内生物利用度相关联，因为通过调节气压可以轻松控制溶出速率，而无需对仪器进行复杂更改，不会出现颗粒过度沉降的情况，并且能够实现药物完全溶解而不会堵塞筛网。
