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本文引用的文献

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THE BINDING OF CALCIUM ION BY THE HUMAN ERYTHROCYTE MEMBRANE.钙离子与人红细胞膜的结合
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PHOSPHOLIPID-CHOLESTEROL MEMBRANE MODEL. I. CORRELATION OF RESISTANCE WITH ION CONTENT. II. CATION EXCHANGE PROPERTIES. 3. EFFECT OF CA ON SALT PERMEABILITY. IV. CA-K UPTAKE BY SONICALLY FRAGMENTED ERYTHROCYTE GHOSTS.磷脂 - 胆固醇膜模型。I. 电阻与离子含量的相关性。II. 阳离子交换特性。3. 钙对盐渗透性的影响。IV. 经超声破碎的红细胞血影对钙 - 钾的摄取
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ROLE OF PHOSPHOLIPIDS IN ATPASE ACTIVITY AND CA TRANSPORT OF FRAGMENTED SARCOPLASMIC RETICULUM.磷脂在肌浆网碎片的ATP酶活性及钙转运中的作用
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MUSCULAR CONTRACTION AS REGULATED BY THE ACTION POTENTIAL.动作电位对肌肉收缩的调节
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BINDING OF CALCIUM IONS TO CELL MEMBRANE ISOLATED FROM BULLFROG SKELETAL MUSCLE.钙离子与从牛蛙骨骼肌分离出的细胞膜的结合
Am J Physiol. 1964 Aug;207:509-12. doi: 10.1152/ajplegacy.1964.207.2.509.
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PHOSPHOLIPID-CHOLESTEROL MEMBRANE MODEL: EFFECTS OF CALCIUM, POTASSIUM OR PROTAMINE ON MEMBRANE HYDRATION, WATER PERMEABILITY AND ELECTRICAL RESISTANCE.磷脂 - 胆固醇膜模型：钙、钾或鱼精蛋白对膜水化、水渗透性和电阻的影响。
J Cell Comp Physiol. 1964 Apr;63:225-32. doi: 10.1002/jcp.1030630213.
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POTENTIATION OF MUSCULAR CONTRACTION.肌肉收缩的增强
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CALCIUM AND MAGNESIUM BINDING PROPERTIES OF CELL MEMBRANE MATERIALS.细胞膜材料的钙镁结合特性
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SODIUM, POTASSIUM AND HYDROGEN ION BINDING CHARACTERISTICS OF DOG ERYTHROCYTE GHOSTS.犬红细胞血影的钠、钾和氢离子结合特性
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The effect of nitrate and other anions on the mechanical response of single muscle fibres.硝酸盐及其他阴离子对单根肌纤维力学反应的影响。
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肌肉收缩增强剂对肌浆网结合阳离子的影响。

Effects of potentiators of muscular contraction on binding of cations by sarcoplasmic reticulum.

作者信息

Carvalho A P

出版信息

J Gen Physiol. 1968 Mar;51(3):427-42. doi: 10.1085/jgp.51.3.427.

DOI:10.1085/jgp.51.3.427
PMID:4231148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2201136/
Abstract

Anionic (NO(3) (-), Br(-), I(-), and SCN(-)) and cationic (Zn(++) and Cd(++)) potentiators of the twitch output of skeletal muscle depress the active binding of Ca by sarcoplasmic reticulum isolated from rabbit skeletal muscle. Zinc and Cd exchange for Ca and Mg at the binding sites of the reticular membranes, whereas the anions effectively induce a replacement by Mg of Ca bound actively in the presence of ATP. In the absence of ATP, the passive binding of both Ca and Mg is increased by the anions tested. Furthermore, the anions increase the total capacity of the membrane fragments for passive cation binding. The Ca-stimulated ATPase activity of the membranes is inhibited by Zn and Cd, but not by the anions. Shifts in cations bound to muscle membrane systems caused by agents that increase the force of contraction developed during the twitch are considered to be the primary event modifying excitation-contraction coupling, and thus leading to potentiation.

摘要

阴离子（硝酸根离子、溴离子、碘离子和硫氰酸根离子）和阳离子（锌离子和镉离子）可增强骨骼肌的抽搐输出，它们会抑制从兔骨骼肌分离出的肌浆网对钙的主动结合。锌和镉在网状膜的结合位点与钙和镁发生交换，而阴离子在ATP存在的情况下能有效促使镁取代主动结合的钙。在没有ATP时，所测试的阴离子会增加钙和镁的被动结合。此外，阴离子还会增加膜碎片对被动阳离子结合的总容量。膜的钙刺激ATP酶活性受到锌和镉的抑制，但不受阴离子的抑制。那些能增加抽搐时产生的收缩力的试剂所引起的与肌肉膜系统结合的阳离子变化，被认为是改变兴奋 - 收缩偶联从而导致增强作用的主要事件。