使用氮特异性检测器快速、灵敏地气相色谱法测定血清中的戊巴比妥及其他巴比妥类药物。
Rapid, sensitive GLC determination of pentobarbital and other barbiturates in serum using nitrogen-specific detector.
作者信息
Sun S R, Hoffman D J
出版信息
J Pharm Sci. 1979 Mar;68(3):386-8. doi: 10.1002/jps.2600680339.
PMID:423139
Abstract
A GLC method for the analysis of pentobarbital in serum was developed. After extraction from serum, a methyl derivative was prepared and quantitated by nitrogen-specific detection. The method has a senstivity of 0.08 microgram/ml for pentobarbital with only 0.1 ml of serum. Secobarbital was the internal standard. Derivatives of other barbiturates also were prepared.
摘要
建立了一种用于分析血清中戊巴比妥的气相色谱法。从血清中提取后，制备甲基衍生物并通过氮特异性检测进行定量。该方法对戊巴比妥的灵敏度为0.08微克/毫升，仅需0.1毫升血清。司可巴比妥为内标。还制备了其他巴比妥类药物的衍生物。
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