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Synthesis and antitumor activity of cyclophosphamide analogues. 2. Preparation, hydrolytic studies, and anticancer screening of 5-bromocyclophosphamide, 3,5-dehydrocyclophosphamide, and related systems.

作者信息

Ludeman S M, Zon G, Egan W

出版信息

J Med Chem. 1979 Feb;22(2):151-8. doi: 10.1021/jm00188a006.

DOI:10.1021/jm00188a006
PMID:423194
Abstract
摘要

相似文献

1
Synthesis and antitumor activity of cyclophosphamide analogues. 2. Preparation, hydrolytic studies, and anticancer screening of 5-bromocyclophosphamide, 3,5-dehydrocyclophosphamide, and related systems.环磷酰胺类似物的合成与抗肿瘤活性。2. 5-溴环磷酰胺、3,5-脱氢环磷酰胺及相关体系的制备、水解研究与抗癌筛选。
J Med Chem. 1979 Feb;22(2):151-8. doi: 10.1021/jm00188a006.
2
Synthesis and antitumor activity of cyclophosphamide analogues. 3. Preparation, molecular structure determination and anticancer screening of racemic cis- and trans-4-phenylcyclophosphamide.环磷酰胺类似物的合成与抗肿瘤活性。3. 外消旋顺式和反式-4-苯基环磷酰胺的制备、分子结构测定及抗癌筛选
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Synthesis and evaluation of 3-halocyclophosphamides and analogous compounds as novel anticancer "pro-prodrugs".
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5-Fluoro- and 5-chlorocyclophosphamide: synthesis, metabolism, and antitumor activity of the cis and trans isomers.5-氟和5-氯环磷酰胺：顺式和反式异构体的合成、代谢及抗肿瘤活性
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Synthesis and antitumor evaluation of 4-ethoxycarbonyl cyclophosphamide analogs.4-乙氧羰基环磷酰胺类似物的合成与抗肿瘤评价
J Pharm Sci. 1978 May;67(5):709-10. doi: 10.1002/jps.2600670539.
6
Synthesis and antitumor activity of cyclophosphamide analogues. 4. Preparation, kinetic studies, and anticancer screening of "phenylketophosphamide" and similar compounds related to the cyclophosphamide metabolite aldophosphamide.环磷酰胺类似物的合成与抗肿瘤活性。4. “苯酮磷酰胺”及与环磷酰胺代谢物醛磷酰胺相关的类似化合物的制备、动力学研究及抗癌筛选。
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7
Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates.环磷酰胺、异环磷酰胺和曲磷胺光学异构体与临床使用的外消旋体相比的抗肿瘤活性。
J Immunopharmacol. 1986;8(4):455-80. doi: 10.3109/08923978609026500.
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The metabolism and antitumour activity of the enantiomers of cis- and trans-4-methylcyclophosphamide.顺式和反式-4-甲基环磷酰胺对映体的代谢及抗肿瘤活性
Chem Biol Interact. 1977 Jul;18(1):47-57. doi: 10.1016/0009-2797(77)90140-5.
9
Novel class of cyclophosphamide prodrug: cyclophosphamide spiropiperaziniums (CPSP).新型环磷酰胺前药：环磷酰胺螺哌嗪鎓盐（CPSP）。
Bioorg Med Chem Lett. 2006 Jul 15;16(14):3727-30. doi: 10.1016/j.bmcl.2006.04.049. Epub 2006 May 6.
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Anodic oxidation of ifosfamide and cyclophosphamide: a biomimetic metabolism model of the oxazaphosphorinane anticancer drugs.
Bioorg Med Chem Lett. 2001 May 21;11(10):1347-9. doi: 10.1016/s0960-894x(01)00218-9.