羟基化吩噻嗪和丙咪嗪衍生物的电化学氧化
Electrochemical oxidation of hydroxylated phenothiazine and imipramine derivatives.
作者信息
Neptune M, McCreery R L, Manian A A
出版信息
J Med Chem. 1979 Feb;22(2):196-9. doi: 10.1021/jm00188a014.
The electrochemical oxidations of several hydroxylated derivatives of promazine, chlorpromazine, imipramine, and 3-chloroimipramine are examined and compared. Oxidation of the monohydroxyphenothiazine derivatives leads to both dihydroxy species and substituted benzoquinones, while oxidation of hydroxylated imipramines leads to only the corresponding benzoquinones. The oxidation potentials of 17 tricyclic psychoactive drugs and metabolites are tabulated and compared. The potential importance of these results to drug activity and side effects is discussed.
对丙嗪、氯丙嗪、丙咪嗪和3-氯丙咪嗪的几种羟基化衍生物的电化学氧化进行了研究和比较。单羟基吩噻嗪衍生物的氧化会生成二羟基物种和取代苯醌，而羟基化丙咪嗪的氧化仅生成相应的苯醌。列出并比较了17种三环类精神活性药物及其代谢物的氧化电位。讨论了这些结果对药物活性和副作用的潜在重要性。
Zotero 插件