羟基化氯丙嗪代谢物的氧化反应。

Oxidative reactions of hydroxylated chlorpromazine metabolites.

作者信息

McCreery R L

出版信息

J Pharm Sci. 1977 Mar;66(3):357-61. doi: 10.1002/jps.2600660313.

Abstract

The oxidation pathways of two hydroxylated chlorpromazine metabolites were investigated using modern electrochemical techniques. Upon oxidation, the 7-hydroxy derivative of chlorpromazine rapidly reacts to form the 7,8-dihydroxy derivative and a substituted quinone. The oxidation potentials for both compounds were determined in the pH 3-8 range. The importance of these redox reactions and potentials to the pharmacology of the materials is discussed.

摘要

利用现代电化学技术研究了两种羟基化氯丙嗪代谢物的氧化途径。氧化时，氯丙嗪的7-羟基衍生物迅速反应生成7,8-二羟基衍生物和一种取代醌。在pH 3 - 8范围内测定了这两种化合物的氧化电位。讨论了这些氧化还原反应和电位对该物质药理学的重要性。