抗肿瘤药物的合成与活性
Synthesis and activities of antitumor agents.
作者信息
Suami T, Machinami T, Hisamatsu T
出版信息
J Med Chem. 1979 Mar;22(3):247-50. doi: 10.1021/jm00189a005.
PMID:423206
Abstract
N-(2-Chloroethyl)-N-nitrosocarbamoyl derivatives of glycosylamines have been prepared. Six N-(2-chloroethyl)-N-nitrosoureas, including three disaccharide derivatives, were submitted to a determination of antitumor activity. All the compounds tested exhibited strong antitumor activity against leukemia L1210 in mice.
摘要
已制备了糖基胺的N-(2-氯乙基)-N-亚硝基氨基甲酰衍生物。六种N-(2-氯乙基)-N-亚硝基脲，包括三种二糖衍生物，被用于抗肿瘤活性测定。所有测试的化合物对小鼠白血病L1210均表现出强烈的抗肿瘤活性。
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