Synthesis and antitumour activity of 4-nitroso-4-(2-chloroethyl)semicarbazides.
作者信息
Gugova R G, Raikov Z D, Zakhariev S G, Demirov G D, Todorov D K, Ilarionova M V
机构信息
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
出版信息
Drugs Exp Clin Res. 1989;15(10):497-500.
PMID:2632217
Abstract
1-Methyl-1-(2-chloroethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide, 1,1-di-(2-chloroethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide and 1,1-di-(2-bromoethyl)-4-nitroso-4-(2-chloroethyl)semicarbazide, which are a novel class of nitrosoureas containing hydrazinomustard residue, have been synthesized. A dose-dependent antitumour activity was found with the three tested compounds.
摘要
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