3,5-二取代吡唑的一些磺酰脲衍生物的制备及其抗糖尿病活性
Preparation and antidiabetic activity of some sulfonylurea derivatives of 3,5-disubstituted pyrazoles.
作者信息
Soliman R
出版信息
J Med Chem. 1979 Mar;22(3):321-5. doi: 10.1021/jm00189a022.
PMID:423216
Abstract
Four series of p-[3,5-dimethyl- (and 5-methyl-3-carboxy-) pyrazole-1]benzenesulfonylureas, thioureas, 2-thiohydantions, and 5,6-dihydro-4(3H)-oxo-2(1H)-pyrimidinethiones were prepared for evaluation as hypoglycemic agents. Biological testing of these compounds showed that some possessed antidiabetic activity.
摘要
制备了四系列对-[3,5-二甲基-(和5-甲基-3-羧基-)吡唑-1]苯磺酰脲、硫脲、2-硫代乙内酰脲和5,6-二氢-4(3H)-氧代-2(1H)-嘧啶硫酮，以评估其作为降血糖剂的活性。对这些化合物的生物学测试表明，其中一些具有抗糖尿病活性。
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