Gagnon J D, Moss W T, Stevens K R
J Urol. 1979 Feb;121(2):182-4. doi: 10.1016/s0022-5347(17)56713-0.
We studied 38 patients with prostatic cancer who received breast irradiation before oral estrogen administration. Our data are combined with those from other institutions to determine the effectiveness of pre-estrogen breast irradiation in minimizing gynecomastia and/or pain. Based on our review the incidence of estrogen-induced breast changes is 70%. Irradiation given before estrogen administration can prevent or minimize these changes in 89.3% of the treated patients. Histologic changes of gynecomastia are reviewed and recommendations for optimum radiation therapy technique are included.
我们研究了38例在口服雌激素之前接受乳房照射的前列腺癌患者。我们的数据与其他机构的数据相结合，以确定雌激素治疗前乳房照射在最小化男性乳房发育和/或疼痛方面的有效性。根据我们的综述，雌激素引起的乳房变化发生率为70%。在给予雌激素之前进行照射可在89.3%的接受治疗的患者中预防或最小化这些变化。对男性乳房发育的组织学变化进行了综述，并包括了最佳放射治疗技术的建议。
