酵母将仲醇氧化为甲基酮。
Oxidation of secondary alcohols to methyl ketones by yeasts.
作者信息
Patel R N, Hou C T, Laskin A I, Derelanko P, Felix A
出版信息
Appl Environ Microbiol. 1979 Aug;38(2):219-23. doi: 10.1128/aem.38.2.219-223.1979.
Abstract
Cell suspensions of yeasts, Candida utilis ATCC 26387, Hansenula polymorpha ATCC 26012, Pichia sp. NRRL-Y-11328, Torulopsis sp. strain A1, and Kloeckera sp. strain A2, grown on various C-1 compounds (methanol, methylamine, methylformate), ethanol, and propylamine catalyzed the oxidation of secondary alcohols to the corresponding methyl ketones. Thus, isopropanol, 2-butanol, 2-pentanol, and 2-hexanol were converted to acetone, 2-butanone, 2-pentanone, and 2-hexanone, respectively. Cell-free extracts derived from methanol-grown yeasts catalyzed an oxidized nicotinamide adenine dinucleotide-dependent oxidation of secondary alcohols to the corresponding methyl ketones, Primary alcohols were not oxidized. The effect of various environmental factors on the production of methyl ketones from secondary alcohols by methanol-grown Pichia sp. was investigated.
摘要
以各种C-1化合物（甲醇、甲胺、甲酸甲酯）、乙醇和丙胺为培养基生长的酵母细胞悬液，如产朊假丝酵母ATCC 26387、多形汉逊酵母ATCC 26012、毕赤酵母属NRRL-Y-11328、球拟酵母属菌株A1和克勒克酵母属菌株A2，可催化仲醇氧化为相应的甲基酮。因此，异丙醇、2-丁醇、2-戊醇和2-己醇分别被转化为丙酮、2-丁酮、2-戊酮和2-己酮。从以甲醇为培养基生长的酵母中提取的无细胞提取物可催化仲醇依赖氧化型烟酰胺腺嘌呤二核苷酸氧化为相应的甲基酮，伯醇则不被氧化。研究了各种环境因素对以甲醇为培养基生长的毕赤酵母属从仲醇生产甲基酮的影响。
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