Griffith B P, Borovetz H S, Hardesty R L, Hung T K, Bahnson H T
J Thorac Cardiovasc Surg. 1979 Apr;77(4):595-601.
A study was undertaken to investigate the applicability of the arteriovenous mode of perfusion for partial support of neonatal respiration. Perigestational lambs, delivered by cesarean section, served as the animal model of respiratory distress. Arteriovenous flow was accomplished between a single umbilical artery and vein. A microchannel membrane oxygenator was used to provide partial respiratory support to the newborn lambs. Total systemic flow, pulmonary blood flow, and pulmonary vascular resistance were assessed at various rates of arteriovenous perfusion and correlated with systemic oxygenation. A reduction in right-to-left shunting of blood and pulmonary vascular resistance occurred as arterial oxygenation rose from conditions of hypoxemia to PaO2 values higher than 50 torr. Myocardial performance was not impaired at rates of arteriovenous perfusion below 30 percent of the total systemic flow, as evidenced by normal electrocardiographic tracings, pulmonary capillary wedge pressures, and central venous pressures. Arteriovenous extracorporeal membrane oxgenation (ECMO) may be particularly suitable for use in infants with hypoxia and high pulmonary vascular resistance.
开展了一项研究以调查动静脉灌注模式用于新生儿呼吸部分支持的适用性。通过剖宫产分娩的围产期羔羊用作呼吸窘迫的动物模型。动静脉血流在单一脐动脉和静脉之间实现。使用微通道膜式氧合器为新生羔羊提供部分呼吸支持。在不同的动静脉灌注速率下评估总全身血流量、肺血流量和肺血管阻力，并将其与全身氧合相关联。随着动脉氧合从低氧血症状态升至高于50托的PaO2值，右向左分流的血液和肺血管阻力降低。当动静脉灌注速率低于总全身血流量的30%时，心肌功能未受损，正常的心电图描记、肺毛细血管楔压和中心静脉压证明了这一点。动静脉体外膜肺氧合（ECMO）可能特别适用于患有缺氧和高肺血管阻力的婴儿。
