Skimming J W, DeMarco V G, Cassin S
Department of Physiology, University of Florida College of Medicine, Gainesville 32610-0296.
Pediatr Res. 1995 Jan;37(1):35-40.
This study was designed to test the hypothesis that inhalation of nitric oxide by lambs delivered prematurely would result in increased systemic arterial blood oxygen tension and decreased pulmonary vascular resistance. Eleven premature fetal lambs were delivered by cesarean section at 126-127 d gestation. One hundred min after the onset of ventilation, nitric oxide gas was added to the lambs' breathing mixture. The animals were exposed in random order to 5 ppm for 10 min, 20 ppm for 10 min, and 20 ppm for 20 min. Each treatment period was preceded by and followed by a 10-min washout period. When compared with the washout (control) periods, all three treatment periods resulted in an improvement in both the systemic arterial blood oxygen tension and the physiologic intrapulmonary shunt. Inhalation of nitric oxide also resulted in a selective decrease in pulmonary arterial blood pressure. Comparisons between the different treatment groups revealed a further improvement in blood oxygenation and pulmonary hemodynamics when using the higher concentration of nitric oxide. Interestingly, the rise in arterial blood oxygenation continued after inhaling 20 ppm nitric oxide for more than 10 min.
对早产羔羊吸入一氧化氮会导致体循环动脉血氧张力升高及肺血管阻力降低。11只妊娠126 - 127天的早产胎儿羔羊通过剖宫产娩出。通气开始100分钟后，将一氧化氮气体添加到羔羊的呼吸混合气中。动物被随机依次暴露于5 ppm持续10分钟、20 ppm持续10分钟以及20 ppm持续20分钟。每个治疗期前后均有10分钟的洗脱期。与洗脱（对照）期相比，所有三个治疗期均使体循环动脉血氧张力和生理性肺内分流得到改善。吸入一氧化氮还导致肺动脉血压选择性降低。不同治疗组之间的比较显示，使用较高浓度的一氧化氮时，血液氧合和肺血流动力学有进一步改善。有趣的是，吸入20 ppm一氧化氮超过10分钟后，动脉血氧合仍持续上升。
