Koronelli T V, Kaliuzhnaia T V
Mikrobiologiia. 1979 Jan-Feb;48(1):62-4.
The effect of isoniazide on the ability to assimilate hydrophilic (sugars) and hydrophobic (hydrocarbon) substrates was studied with saprophytic mycobacteria. The minimal concentration of isoniazide inhibiting the growth of saprophytic mycobacteria in a medium containing hexadecane was 150 mcg/ml. If isoniazide was added at a concentration of 900 mcg/ml at the beginning of the logarithmic growth phase, the growth was sharply inhibited and assimilation of the hydrocarbon decelerated 4 times. The same concentration of isoniazide hardly affected the growth of the saprophytic mycobacteria in a medium containing a carbohydrate.
利用腐生分枝杆菌研究了异烟肼对同化亲水性（糖类）和疏水性（烃类）底物能力的影响。在含有十六烷的培养基中，抑制腐生分枝杆菌生长的异烟肼最低浓度为150微克/毫升。如果在对数生长期开始时以900微克/毫升的浓度添加异烟肼，生长会受到急剧抑制，烃类的同化作用减慢4倍。相同浓度的异烟肼对含有碳水化合物的培养基中腐生分枝杆菌的生长几乎没有影响。
