Merrills R J, Shaw J T
Biochem J. 1968 Jan;106(1):101-5. doi: 10.1042/bj1060101.
The principles relating the lysis times of fibrin clots to their contents of fibrin, plasminogen and plasminogen-activator were investigated. Mathematical considerations suggested that the square of the lysis time should correlate linearly with the fibrin content, and inversely with the activator and the plasminogen contents of the system. Experimental studies, during which these parameters were independently varied, showed that the predicted relationships were valid for concentrations that gave clot-lysis times in the range normally used for studies of fibrinolysis.
研究了纤维蛋白凝块溶解时间与其纤维蛋白、纤溶酶原和纤溶酶原激活剂含量之间的关系。数学分析表明，溶解时间的平方应与纤维蛋白含量呈线性相关，与系统中的激活剂和纤溶酶原含量呈反比。在这些参数独立变化的实验研究中，结果表明，对于在通常用于纤维蛋白溶解研究的范围内产生凝块溶解时间的浓度，预测的关系是有效的。
