Galeano C, Leung C Y, Robitaille R, Roy-Chabot T
Départment de Physiologie et Pharmacologie, Université de Sherbrooke, Centre Hospitalier Universitaire, Sherbrooke, Que. J1H 5N4 Canada.
Pain. 1979 Feb;6(1):71-81. doi: 10.1016/0304-3959(79)90141-6.
The aim of this study was to verify the validity and reliability of analgesia elicited by acupuncture stimulation in rabbits. Ninety-five experiments were performed using 21 adult animals. The reaction time of the avoidance response elicited by noxious heat stimulation on the snout, and the presence or absence of the start response elicited by pin-prick and clamping of the skin were studied. Bilateral electric acupuncture stimulation in the area of Tsu-san-li and Shang-chu-hsu points in the hind legs was used. The animals were either held in a soft bag, loosely attached by cords, or suspended in a hammock; the eyes were either free of blindfolded. On the basis of operational behavioral measurements, it was found that acupuncture stimulation did not produce analgesia in undisturbed, placid animals. However, during agitated or fighting periods and the immobility reflex-like state, sometimes associated with acupuncture maneuvers, long reaction times were observed. Pin-pricking and clamping stimulation of the skin were not reliable methods of noxious stimulation in the rabbit.
本研究的目的是验证针刺刺激在兔身上引起的镇痛作用的有效性和可靠性。使用21只成年动物进行了95次实验。研究了对兔鼻有害热刺激引发的回避反应的反应时间，以及针刺和夹捏皮肤引发的起始反应的有无。采用双侧电针刺激后腿的足三里和上巨虚穴位区域。动物要么被放在一个软袋里，用绳子松散地系着，要么被悬挂在吊床上；眼睛要么不蒙眼罩，要么蒙住。基于操作性行为测量，发现在未受干扰、安静的动物中针刺刺激不会产生镇痛作用。然而，在激动或争斗期间以及有时与针刺操作相关的类似不动反射的状态下，观察到了较长的反应时间。针刺和夹捏皮肤刺激对兔来说不是可靠的有害刺激方法。
