雄性和雌性小鼠中硫酸雄激素的形成。
Androgen sulphate formation in male and female mice.
作者信息
Lewis D A
出版信息
Biochem J. 1969 Nov;115(3):489-93. doi: 10.1042/bj1150489.
Abstract
- After the administration of large doses of androsterone, epiandrosterone, dehydroepiandrosterone and testosterone to mice, females excreted more of the dose conjugated with sulphuric acid than did males. 2. Liver slices from female mice conjugated androgens with sulphuric acid to a greater extent than did slices from males. 3. Sulphotransferase preparations from livers of female rats and mice catalysed the formation of dehydroepiandrosterone sulphate at a faster rate than preparations from livers of the male animals. 4. A possible explanation for the observed sex differences is discussed.
摘要
- 给小鼠注射大剂量的雄酮、表雄酮、脱氢表雄酮和睾酮后，雌性小鼠排出的与硫酸结合的剂量比雄性小鼠更多。2. 雌性小鼠的肝切片比雄性小鼠的肝切片更能将雄激素与硫酸结合。3. 雌性大鼠和小鼠肝脏的硫酸转移酶制剂催化生成硫酸脱氢表雄酮的速度比雄性动物肝脏的制剂更快。4. 讨论了观察到的性别差异的一种可能解释。
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