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雄性和雌性大鼠中硫酸雄激素的形成。

Androgen sulphate formation in male and female rats.

作者信息

Lewis D A

出版信息

Biochem J. 1968 Jan;106(2):497-501. doi: 10.1042/bj1060497.

DOI:10.1042/bj1060497
PMID:5637356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1198529/
Abstract
  1. After large doses of androsterone, epiandrosterone, dehydroepiandrosterone and testosterone, female rats excreted more of the dose conjugated with sulphuric acid than did the males. 2. Androgens were also incubated with liver slices from male and female rats. Slices from females conjugated androgens with sulphuric acid to a greater extent than did slices from males. 3. The amount of unchanged androgen present in the faeces of orally dosed animals was 4-35% of the dose.
摘要
  1. 给雌性大鼠注射大剂量的雄酮、表雄酮、脱氢表雄酮和睾酮后，其排出的与硫酸结合的剂量比雄性大鼠更多。2. 将雄激素也与雄性和雌性大鼠的肝切片一起孵育。雌性大鼠的肝切片比雄性大鼠的肝切片更能将雄激素与硫酸结合。3. 经口给药动物粪便中未变化的雄激素量为给药剂量的4%-35%。

相似文献

1
Androgen sulphate formation in male and female rats.雄性和雌性大鼠中硫酸雄激素的形成。
Biochem J. 1968 Jan;106(2):497-501. doi: 10.1042/bj1060497.
2
Androgen sulphate formation in male and female mice.雄性和雌性小鼠中硫酸雄激素的形成。
Biochem J. 1969 Nov;115(3):489-93. doi: 10.1042/bj1150489.
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In vivo sulfation of cholesterol by ascorbic acid 2-sulfate.
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Sex differences in androgen sulphate formation in rats and mice.大鼠和小鼠中硫酸雄激素形成的性别差异。
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[Direct metabolism of intravenously injected dehydroepiandrosterone-7-alpha-3H-sulfate-35S at the end of normal pregnancy].
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[On the metabolism of phosphates and sulfates of androsterone and epiandrosterone].[关于雄甾酮和表雄甾酮的磷酸盐和硫酸盐的代谢]
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Comparative roles of dehydroepiandrosterone sulfate and androstenediol sulfate as precursors of testicular androgens.硫酸脱氢表雄酮和硫酸雄烯二醇作为睾丸雄激素前体的比较作用。
Endocrinology. 1970 Aug;87(2):316-22. doi: 10.1210/endo-87-2-316.

引用本文的文献

1
Androgen sulphate formation in male and female mice.雄性和雌性小鼠中硫酸雄激素的形成。
Biochem J. 1969 Nov;115(3):489-93. doi: 10.1042/bj1150489.
2
Sex differences in androgen sulphate formation in rats and mice.大鼠和小鼠中硫酸雄激素形成的性别差异。
Biochem J. 1968 Sep;109(2):12P-13P. doi: 10.1042/bj1090012pb.

本文引用的文献

1
Substrate and inhibitor specificity of the cholesterol oxidase in bovine adrenal cortex.牛肾上腺皮质胆固醇氧化酶的底物和抑制剂特异性。
Biochem J. 1966 Dec;101(3):819-30. doi: 10.1042/bj1010819.
2
THE METABOLISM OF PROGESTERONE BY ANIMAL TISSUES IN VITRO. SEX AND SPECIES DIFFERENCES IN CONJUGATE FORMATION DURING THE METABOLISM OF (4-14C)PROGESTERONE BY LIVER HOMOGENATES.动物组织体外孕酮代谢。肝匀浆对（4-¹⁴C）孕酮代谢过程中结合物形成的性别和物种差异。
Biochem J. 1965 Jul;96(1):172-80. doi: 10.1042/bj0960172.
3
AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.一种肾上腺分泌的“雄激素”：硫酸脱氢表雄酮。其代谢以及对人体其他甾体共轭物代谢的初步概括。
Recent Prog Horm Res. 1965;21:411-500.
4
EVIDENCE THAT STEROID SULFATES SERVE AS BIOSYNTHETIC INTERMEDIATES. II. IN VITRO CONVERSION OF PREGNENOLONE-3H SULFATE-35S TO 17ALPHA-HYDROXYPREGNENOLONE-3H SULFATE-35S.
Biochemistry. 1964 Feb;3:259-64. doi: 10.1021/bi00890a020.
5
EVIDENCE THAT STEROID SULFATES SERVE AS BIOSYNTHETIC INTERMEDIATES: IN VIVO CONVERSION OF PREGNENOLONE-SULFATE-S35 TO DEHYDROISOANDROSTERONE SULFATE-S35.
Biochemistry. 1963 Jul-Aug;2:648-53. doi: 10.1021/bi00904a005.
6
The effect of development on the composition of a long bone of the pig, rat and fowl.发育对猪、大鼠和禽类长骨组成的影响。
Biochem J. 1962 Jan;82(1):47-55. doi: 10.1042/bj0820047.
7
Some aspects of the Zimmermann reaction.齐默尔曼反应的某些方面。
Biochem J. 1962 Jun;83(3):583-8. doi: 10.1042/bj0830583.
8
The 16alpha-hydroxylation of dehydroepiandrosterone (3 beta-hydroxyandrost-5-en-17-one) by rat-liver slices.大鼠肝脏切片对脱氢表雄酮（3β-羟基雄甾-5-烯-17-酮）的16α-羟基化作用。
Biochem J. 1962 Mar;82(3):390-4. doi: 10.1042/bj0820390.
9
Influence of age, sex and adrenocortical status on hepatic reduction of cortisone in vitro.
Endocrinology. 1960 Aug;67:194-203. doi: 10.1210/endo-67-2-194.
10
Further studies on the sex difference in 3 beta-hydroxysteroid dehydrogenase activity of rat livers.大鼠肝脏3β-羟基类固醇脱氢酶活性性别差异的进一步研究。
Endocrinology. 1961 Aug;69:257-67. doi: 10.1210/endo-69-2-257.