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在来自鳟鱼睾丸的假定具有转录活性的染色质组分中发现了H4的多乙酰化形式。

Multiacetylated forms of H4 are found in a putative transcriptionally competent chromatin fraction from trout testis.

作者信息

Levy-Wilson B, Watson D C, Dixon G H

出版信息

Nucleic Acids Res. 1979 Jan;6(1):259-74. doi: 10.1093/nar/6.1.259.

DOI:10.1093/nar/6.1.259
PMID:424292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327687/
Abstract

We have examined the distribution of acetylated histones derived from various trout testis chromatin fractions of different composition. Our results indicate that a chromatin fraction, preferentially solubilized by micrococcal nuclease, containing the bulk of the HMG proteins and similar to a fraction released from intact trout nuclei and previously shown to be enriched in transcribed DNA sequences also possesses high levels of multiacetylated species of H4. Histones 2A, 2B and 3 are also acetylated in this particular chromatin fraction. Monoacetylated species of the 4 inner nucleosomal histones appear to be characteristic of the nucleohistone portion of trout testis chromatin.

摘要

我们已经检测了源自不同组成的各种鲑鱼睾丸染色质组分的乙酰化组蛋白的分布情况。我们的结果表明，一个优先被微球菌核酸酶溶解的染色质组分，含有大部分的HMG蛋白，类似于从完整的鲑鱼细胞核中释放出来且先前已证明富含转录DNA序列的一个组分，它也具有高水平的多乙酰化H4物种。组蛋白2A、2B和3在这个特定的染色质组分中也被乙酰化。4种内核小体组蛋白的单乙酰化物种似乎是鲑鱼睾丸染色质核组蛋白部分的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/dc37ce6b4ed3/nar00442-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/5a885784684e/nar00442-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/632e5e002b0a/nar00442-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/dc37ce6b4ed3/nar00442-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/5a885784684e/nar00442-0267-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/632e5e002b0a/nar00442-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba5b/327687/dc37ce6b4ed3/nar00442-0271-a.jpg

相似文献

1
Multiacetylated forms of H4 are found in a putative transcriptionally competent chromatin fraction from trout testis.在来自鳟鱼睾丸的假定具有转录活性的染色质组分中发现了H4的多乙酰化形式。
Nucleic Acids Res. 1979 Jan;6(1):259-74. doi: 10.1093/nar/6.1.259.
2
Chromatin subunits contain normal levels of major acetylated histone species.染色质亚基含有正常水平的主要乙酰化组蛋白种类。
J Biol Chem. 1977 Sep 10;252(17):5962-6.
3
Distribution of high mobility group proteins among domains of trout testis chromatin differing in their susceptibility to micrococcal nuclease.高迁移率族蛋白在对微球菌核酸酶敏感性不同的鳟鱼睾丸染色质结构域中的分布。
J Biol Chem. 1980 Feb 10;255(3):1090-5.
4
Partial purification of transcriptionally active nucleosomes from trout testis cells.从鳟鱼睾丸细胞中对转录活性核小体进行部分纯化。
Nucleic Acids Res. 1978 Nov;5(11):4155-63. doi: 10.1093/nar/5.11.4155.
5
A subset of trout testis nucleosomes enriched in transcribed DNA sequences contains high mobility group proteins as major structural components.在富含转录DNA序列的虹鳟鱼睾丸核小体亚组中，高迁移率族蛋白作为主要结构成分存在。
J Biol Chem. 1979 Feb 10;254(3):609-20.
6
Characterization and chromatin distribution of the H1 histones and high-mobility-group non-histone chromosomal proteins of trout liver and hepatocellular carcinoma.鳟鱼肝脏和肝细胞癌中H1组蛋白及高迁移率族非组蛋白染色体蛋白的特性与染色质分布
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Transcriptionally active mononucleosomes from trout testis are heterogeneous in composition.来自鳟鱼睾丸的转录活性单核小体在组成上是异质的。
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8
Acetylated histone H4 is preferentially associated with template-active chromatin.乙酰化组蛋白H4优先与模板活性染色质相关联。
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3574-7. doi: 10.1073/pnas.75.8.3574.
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Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences.丁酸盐对组蛋白去乙酰化的抑制作用导致组蛋白H3和H4的多乙酰化形式积累，并增加相关DNA序列对DNase I的敏感性。
Proc Natl Acad Sci U S A. 1978 May;75(5):2239-43. doi: 10.1073/pnas.75.5.2239.
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Histone H4 hyperacetylation and rapid turnover of its acetyl groups in transcriptionally inactive rooster testis spermatids.转录不活跃的公鸡睾丸精子细胞中组蛋白H4的高度乙酰化及其乙酰基团的快速周转。
Nucleic Acids Res. 1982 Dec 20;10(24):8049-59. doi: 10.1093/nar/10.24.8049.

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2
Purification and initial characterization of primate satellite chromatin.灵长类卫星染色质的纯化及初步表征
Chromosome Res. 1999;7(5):341-54. doi: 10.1023/a:1009211929408.
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Carnitine suppression of position-effect variegation in Drosophila melanogaster.果蝇中肉碱对位置效应斑驳的抑制作用。

本文引用的文献

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Developmental changes in chromosomal composition and template activity during spermatogenesis in trout testis.虹鳟鱼睾丸精子发生过程中染色体组成和模板活性的发育变化。
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Histone acetylation by cell-free preparations from rat uterus: in vitro stimulation by estradiol-17 beta.大鼠子宫无细胞制剂的组蛋白乙酰化：17β-雌二醇的体外刺激作用
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In vitro transcription of chromatin containing histones hyperacetylated in vivo.对体内组蛋白发生超乙酰化的染色质进行体外转录。
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Acetylation of histones in nucleosomes.核小体中组蛋白的乙酰化作用。
Mol Cell Biochem. 1982 Apr 30;44(2):113-28. doi: 10.1007/BF00226895.
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Butyrate suppression of position-effect variegation in Drosophila melanogaster.丁酸盐对黑腹果蝇位置效应斑驳的抑制作用。
Mol Gen Genet. 1980;178(2):465-9. doi: 10.1007/BF00270501.
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Hyperacetylation of histone H4 promotes chromatin decondensation prior to histone replacement by protamines during spermatogenesis in rainbow trout.在虹鳟鱼精子发生过程中，组蛋白H4的高度乙酰化在精蛋白取代组蛋白之前促进染色质解聚。
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Carbohydrate modifications of the high mobility group proteins.高迁移率族蛋白的碳水化合物修饰
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Partial inhibition of histone deacetylase in active chromatin by HMG 14 and HMG 17.HMG 14和HMG 17对活性染色质中组蛋白脱乙酰酶的部分抑制作用。
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Changing patterns of histone acetylation and RNA synthesis in regeneration of the liver.肝脏再生过程中组蛋白乙酰化和RNA合成模式的变化
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RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.淋巴细胞基因激活过程中的RNA合成与组蛋白乙酰化。
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Acetylation of trout testis histones in vivo. Site of the modification in histone IIb 1 .鳟鱼睾丸组蛋白在体内的乙酰化作用。组蛋白IIb 1的修饰位点。
J Biol Chem. 1972 Jun 25;247(12):3868-73.
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Histones: structure and function.组蛋白：结构与功能
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Studies on histone fraction F2A1 in macro- and micronuclei of Tetrahymena pyriformis.梨形四膜虫大核和小核中组蛋白F2A1的研究。
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Enzymatic modifications and their possible roles in regulating the binding of basic proteins to DNA and in controlling chromosomal structure.酶促修饰及其在调节碱性蛋白质与DNA结合以及控制染色体结构方面可能发挥的作用。
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