Zemliakova Z M, Kravets E B
Probl Endokrinol (Mosk). 1979 Mar-Apr;25(2):25-8.
Complex clinical and laboratory research of nonspecific immunobiological reactivity was conducted in 86 children (35 with diabetes mellitus, 25 with obesity, and 26 healthy children), aged from 3 to 14 years. Lysozyme activity and complement titre were studied during the disease. Reduced reactive possibilities of the organism were demonstrated in diabetic children; reduction of these parameters was directly proportional to the severity of the main process and the extent of decompensation. In obese patients the parameters of nonspecific reactivity tests were higher than in healthy children, and glucose tolerance was disturbed; this was apparently connected with stress of the compensatory-defense mechanisms of the organism. A distinct reduction of the parameters in this group of children under the effect of unfavourable factors pointed to exhaustion of the compensatory mechanisms. Obese patients should be referred to the group of children will increased risk, both in respect to diabetes mellitus and to other diseases. The indices under study could be applied as tests characterizing not only the immunobiological reactivity and the defense-adaptive mechanisms of the organism, but also the severity and phase of the disease.
对86名3至14岁的儿童（35名糖尿病患儿、25名肥胖患儿和26名健康儿童）进行了非特异性免疫生物学反应的复杂临床和实验室研究。在疾病期间研究了溶菌酶活性和补体滴度。糖尿病患儿机体的反应可能性降低；这些参数的降低与主要病程的严重程度和失代偿程度直接相关。肥胖患者非特异性反应性测试的参数高于健康儿童，且葡萄糖耐量受到干扰；这显然与机体代偿防御机制的应激有关。在不利因素的影响下，这组儿童的参数明显降低，表明代偿机制耗竭。肥胖患者应被归为患病风险增加的儿童组，无论是患糖尿病还是其他疾病。所研究的指标不仅可作为表征机体免疫生物学反应和防御适应机制的测试，还可用于表征疾病的严重程度和阶段。
