淋巴细胞转化与免疫反应之间的关系。II. 转化与体液免疫和细胞免疫反应之间的相关性。
The relationship between lymphocyte transformation and immune responses. II. Correlations between transformation and humoral and cellular immune responses.
作者信息
Benezra D, Gery I, Davies A M
出版信息
Clin Exp Immunol. 1969 Jul;5(1):155-61.
Abstract
Rabbits were immunized against purified proteins, tissue extracts or sheep erythrocytes, with or without Freund's adjuvant. Skin reactions of the delayed type were found only in animals given antigen with adjuvant, although all rabbits developed serum antibodies and most of them Arthus type reactions. Lymphocytes of all animals, however, showed similar transformation activity when cultured with the immunizing antigen. Thus the blast transformation phenomenon correlates well with both cellular and humoral immune responses and not with the delayed type hypersensitivity only.
摘要
用纯化蛋白、组织提取物或绵羊红细胞对兔子进行免疫，使用或不使用弗氏佐剂。仅在给予佐剂抗原的动物中发现迟发型皮肤反应，尽管所有兔子都产生了血清抗体，并且大多数兔子出现了阿瑟斯型反应。然而，当用免疫抗原培养时，所有动物的淋巴细胞都表现出相似的转化活性。因此，母细胞转化现象与细胞免疫和体液免疫反应都密切相关，而不仅仅与迟发型超敏反应相关。
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