Yasuhara H, Dujovne C A, Ueda I
Pharmacology. 1979;18(2):95-102. doi: 10.1159/000137236.
Chang liver cell cultures were exposed to the tricyclic antidepressants, chlorimipramine (CIM), nortriptyline (NT), amitriptyline (AT), imipramine (IM), and dosepin (DOX). Loss of enzymes into surrounding media and cytopathic changes were used to quantitate cytotoxicity. Time- and concentration-related cytotoxic effects were evident for all drugs. The order of cytotoxic potency was CIM greater than NT greater than AT greater than IM greater than DOX. All tricyclic antidepressants tested lowered the surface tension of the salt solution contained in the tissue culture media and the order of their surface activity was identical to that of their cytotoxicity. It is postulated that the cellular toxicity induced by tricyclic antidepressants in vitro is related to a function of their surface activity.
将Chang肝细胞培养物暴露于三环类抗抑郁药氯米帕明（CIM）、去甲替林（NT）、阿米替林（AT）、丙咪嗪（IM）和多塞平（DOX）中。通过测定释放到周围培养基中的酶以及细胞病变变化来定量细胞毒性。所有药物均呈现出与时间和浓度相关的细胞毒性作用。细胞毒性强度顺序为CIM＞NT＞AT＞IM＞DOX。所有测试的三环类抗抑郁药均降低了组织培养基中盐溶液的表面张力，且它们的表面活性顺序与其细胞毒性顺序相同。据推测，三环类抗抑郁药在体外诱导的细胞毒性与其表面活性功能有关。
