Enzymes for trauma.

We will discuss the mechanism of action, efficacy and side-effects of the proteolytic enzymes. Their exact mechanism of action remains vague which may be partly responsible for the uncertainty about their therapeutic value. Use of chymotrypsin (Alpha-Chymar) in lens extractions has gained general acceptance and the topical use of trypsin-chymotrypsin (Biozyme), streptokinase-streptodornase (Varidase) and fibrinolysin-desoxyribonuclease (Elase) will also be shown to be of some value. The merits of oral, buccal or intramuscular administration, however, will not be conclusively demonstrated. Studies showing favourable results for non-topically administered enzymes are not completely acceptable, primarily due to the lack of precise techniques of measurement. The effectiveness of systemically administered preparations of proteolytic enzymes as anti-inflammatory agents will remain to be established.