雏鸡内毒素研究：醋酸铅的作用
Endotoxin studies in chicks: effect of lead acetate.
作者信息
Truscott R B
出版信息
Can J Comp Med. 1970 Apr;34(2):134-7.
Abstract
Lead acetate administered intravenously in a mixture with endotoxin preparations potentiates the toxic effect of endotoxin for 14-21 day old meat strain chicks. A dose of 2.8 mg of lead acetate/100 g body weight is more effective with endotoxin than a dose of 2.5 mg; however, a dose of 3.0 mg or greater is toxic alone. The degree of potentiation appears to be at least 1000 fold and permits toxicity determinations using endotoxin levels ranging from 0.125 microg to 250 microg/chick. Endotoxin preparations made using NaCl, TCA or phenol-water extraction procedures, possessed toxic activity for chicks when tested by this method.
摘要
将醋酸铅与内毒素制剂混合静脉注射，可增强内毒素对14 - 21日龄肉用型雏鸡的毒性作用。每100克体重注射2.8毫克醋酸铅的剂量与内毒素联合使用时比2.5毫克的剂量更有效；然而，3.0毫克或更高剂量的醋酸铅单独使用时具有毒性。增强程度似乎至少为1000倍，这使得可以使用每只雏鸡0.125微克至250微克范围内的内毒素水平来测定毒性。用氯化钠、三氯乙酸或酚 - 水提取程序制备的内毒素制剂，用此方法检测时对雏鸡具有毒性活性。
相似文献
1
Endotoxin studies in chicks: effect of lead acetate.雏鸡内毒素研究：醋酸铅的作用
Can J Comp Med. 1970 Apr;34(2):134-7.
2
Metabolic manifestations of lead acetate sensitization to endotoxin in mice.醋酸铅致敏小鼠对内毒素的代谢表现
J Reticuloendothel Soc. 1973 Jun;13(6):527-35.
3
Toxicity, clearance and distribution of endotoxin in mice as influenced by actinomycin D, cycloheximide, -amanitin and lead acetate.放线菌素D、环己酰亚胺、α-鹅膏蕈碱和醋酸铅对小鼠体内内毒素的毒性、清除及分布的影响
Toxicon. 1972 Aug;10(5):491-500. doi: 10.1016/0041-0101(72)90175-4.
4
Effect of lead acetate on the susceptibility of rats to bacterial endotoxins.醋酸铅对大鼠细菌内毒素易感性的影响。
J Bacteriol. 1966 Feb;91(2):884-90. doi: 10.1128/jb.91.2.884-890.1966.
5
Failure of oral Escherichia coli endotoxin to induce either specific tolerance or toxic symptoms in rats.口服大肠杆菌内毒素未能在大鼠中诱导特异性耐受或毒性症状。
J Pathol Bacteriol. 1968 Oct;96(2):481-6. doi: 10.1002/path.1700960227.
6
Potentiation of endotoxin-induced consumptive coagulopathy by lead acetate administration.醋酸铅给药对内毒素诱导的消耗性凝血病的增强作用。
Infect Immun. 1974 Dec;10(6):1343-9. doi: 10.1128/iai.10.6.1343-1349.1974.
7
Sensitivity of adrenalectomized rats to lead and lead-endotoxin combinations.肾上腺切除大鼠对铅及铅-内毒素组合的敏感性。
J Lab Clin Med. 1971 Dec;78(6):981.
8
Enhancement by lead acetate of body weight-decreasing activity of endotoxin: quantitative comparisons of some administration methods of lead acetate.醋酸铅对内毒素体重减轻活性的增强作用：醋酸铅某些给药方法的定量比较。
Jpn J Med Sci Biol. 1980 Aug;33(4):203-16. doi: 10.7883/yoken1952.33.203.
9
Studies on the serological and immunological response of chickens to endotoxin and endotoxoid.鸡对内毒素和类毒素的血清学及免疫反应研究。
Can J Comp Med. 1972 Apr;36(2):170-7.
10
Stability of Escherichia coli endotoxin in the rat gastro-intestinal tract.大肠杆菌内毒素在大鼠胃肠道中的稳定性。
J Pathol Bacteriol. 1968 Oct;96(2):487-91. doi: 10.1002/path.1700960228.
引用本文的文献
1
Lead poisoning in chickens and the effect of lead on interferon and antibody production.鸡的铅中毒以及铅对干扰素和抗体产生的影响。
Can J Comp Med. 1974 Jul;38(3):328-35.
2
Studies on the serological and immunological response of chickens to endotoxin and endotoxoid.鸡对内毒素和类毒素的血清学及免疫反应研究。
Can J Comp Med. 1972 Apr;36(2):170-7.
3
The transfer of endotoxin induced immunity from hens to poults.内毒素诱导的免疫力从母鸡到雏禽的转移。
Can J Comp Med. 1972 Jan;36(1):64-8.
4
Cadmium-induced phagocyte cytotoxicity.镉诱导的吞噬细胞细胞毒性。
Bull Environ Contam Toxicol. 1978 Nov;20(5):582-8. doi: 10.1007/BF01683568.
5
Impaired host resistance to endotoxin and malaria in polychlorinated biphenyl- and hexachlorobenzene-treated mice.多氯联苯和六氯苯处理的小鼠对内毒素和疟疾的宿主抵抗力受损。
Infect Immun. 1978 Apr;20(1):30-5. doi: 10.1128/iai.20.1.30-35.1978.
本文引用的文献
1
Mutants of Escherichia coli requiring methionine or vitamin B12.需要甲硫氨酸或维生素B12的大肠杆菌突变体。
J Bacteriol. 1950 Jul;60(1):17-28. doi: 10.1128/jb.60.1.17-28.1950.
2
SPECIES RESISTANCE TO HISTAMINE AND ENDOTOXIN: THE RESPONSE OF THE CHICKEN.物种对组胺和内毒素的抵抗力：鸡的反应
Proc Soc Exp Biol Med. 1964 Feb;115:455-8. doi: 10.3181/00379727-115-28940.
3
Comparative studies on the toxicity of Escherichia coli lipopolysaccharide endotoxin in various animal species.
Can J Microbiol. 1966 Oct;12(5):1070-1. doi: 10.1139/m66-143.
4
Relation of structure to function in bacterial O-antigens. V. Nature of active sites in endotoxic lipopolysaccharides of Serratia marcescens.细菌O抗原中结构与功能的关系。V. 粘质沙雷氏菌内毒素脂多糖中活性位点的性质。
Ann N Y Acad Sci. 1966 Jun 30;133(2):604-21. doi: 10.1111/j.1749-6632.1966.tb52392.x.
5
Effect of lead acetate on the susceptibility of rats to bacterial endotoxins.醋酸铅对大鼠细菌内毒素易感性的影响。
J Bacteriol. 1966 Feb;91(2):884-90. doi: 10.1128/jb.91.2.884-890.1966.
6
Chemical analyses of the blood of chicks infected or endointoxicated with Escherichia coli.对感染大肠杆菌或发生内毒素中毒的雏鸡血液进行的化学分析。
Poult Sci. 1965 Nov;44(6):1551-5. doi: 10.3382/ps.0441551.
Zotero 插件