雏鸡内毒素研究：醋酸铅的作用
Endotoxin studies in chicks: effect of lead acetate.
作者信息
Truscott R B
出版信息
Can J Comp Med. 1970 Apr;34(2):134-7.
Abstract
Lead acetate administered intravenously in a mixture with endotoxin preparations potentiates the toxic effect of endotoxin for 14-21 day old meat strain chicks. A dose of 2.8 mg of lead acetate/100 g body weight is more effective with endotoxin than a dose of 2.5 mg; however, a dose of 3.0 mg or greater is toxic alone. The degree of potentiation appears to be at least 1000 fold and permits toxicity determinations using endotoxin levels ranging from 0.125 microg to 250 microg/chick. Endotoxin preparations made using NaCl, TCA or phenol-water extraction procedures, possessed toxic activity for chicks when tested by this method.
摘要
将醋酸铅与内毒素制剂混合静脉注射，可增强内毒素对14 - 21日龄肉用型雏鸡的毒性作用。每100克体重注射2.8毫克醋酸铅的剂量与内毒素联合使用时比2.5毫克的剂量更有效；然而，3.0毫克或更高剂量的醋酸铅单独使用时具有毒性。增强程度似乎至少为1000倍，这使得可以使用每只雏鸡0.125微克至250微克范围内的内毒素水平来测定毒性。用氯化钠、三氯乙酸或酚 - 水提取程序制备的内毒素制剂，用此方法检测时对雏鸡具有毒性活性。
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