鸡的铅中毒以及铅对干扰素和抗体产生的影响。
Lead poisoning in chickens and the effect of lead on interferon and antibody production.
作者信息
Vengris V E, Maré C J
出版信息
Can J Comp Med. 1974 Jul;38(3):328-35.
The effect of aqueous lead acetate given per os to chickens for 35 consecutive days and the effect of lead on interferon and antibody production was investigated. Chickens were found to tolerate levels of lead as high as 160 mg/kg/day without exhibiting clinical signs or hematological changes in spite of very high levels of lead in the blood (6.2 ppm). It is apparent from these findings that chickens are more resistant to lead poisoning than humans, horses, dogs and wild fowl such as ducks. Subclinical lead doses did not affect interferon induction in response to statolon and Newcastle Disease virus (NDV)-B(1). Interferon concentrations and duration in serum were markedly decreased in chickens which received lead at the 320 mg/kg level. Long time lead exposure had no marked effect on antibody production to NDV in chickens. No consistent correlation was observed between blood lead concentration and antibody titer. The results of these studies indicate that long term subclinical lead intake suppresses neither interferon nor antibody production in chickens.
研究了连续35天经口给鸡投喂醋酸铅水溶液的效果以及铅对干扰素和抗体产生的影响。尽管血液中铅含量非常高（6.2 ppm），但发现鸡能够耐受高达160毫克/千克/天的铅水平，而不表现出临床症状或血液学变化。从这些发现可以明显看出，鸡比人类、马、狗和野鸭等野生禽类对铅中毒更具抵抗力。亚临床铅剂量并不影响鸡对静注放线菌素和新城疫病毒（NDV）-B（1）的干扰素诱导。接受320毫克/千克水平铅的鸡血清中干扰素浓度和持续时间显著降低。长期铅暴露对鸡新城疫病毒抗体产生没有显著影响。血液铅浓度与抗体滴度之间未观察到一致的相关性。这些研究结果表明，长期亚临床铅摄入既不抑制鸡的干扰素产生，也不抑制抗体产生。
Zotero 插件