全科医疗中药物的不良反应。
Adverse reactions to drugs in general practice.
作者信息
Martys C R
出版信息
Br Med J. 1979 Nov 10;2(6199):1194-7. doi: 10.1136/bmj.2.6199.1194.
Abstract
Of 817 patients in a general-practice survey of adverse reactions to drugs, 41% were thought to have "certainly" or "probably" had a reaction to the drug prescribed. Adverse effects on the gastrointestinal and central nervous systems were the most frequently reported, and 90% of reactions had occurred by the fourth day of treatment. More patients given drugs acting on the central nervous system and antihistamines reported reactions than those in other categories. A higher incidence of adverse drug effects is shown in this general-practice survey than in other, mainly hospital-based, surveys. Further intensive surveillance for adverse effects of drugs is recommended to provide additional information on the burden of drug-induced disease in the community.
摘要
在一项关于药物不良反应的全科医疗调查中，817名患者中有41%被认为“肯定”或“很可能”对所开药物有不良反应。对胃肠道和中枢神经系统的不良反应是最常报告的，90%的反应在治疗的第四天就已出现。与其他类别相比，使用作用于中枢神经系统的药物和抗组胺药的患者报告的反应更多。这项全科医疗调查显示的药物不良反应发生率高于其他主要基于医院的调查。建议对药物不良反应进行进一步的强化监测，以提供关于社区中药物性疾病负担的更多信息。
相似文献
1
Adverse reactions to drugs in general practice.全科医疗中药物的不良反应。
Br Med J. 1979 Nov 10;2(6199):1194-7. doi: 10.1136/bmj.2.6199.1194.
2
Emergency department visits caused by adverse drug events: results of a French survey.药物不良事件导致的急诊科就诊：一项法国调查的结果
Drug Saf. 2007;30(1):81-8. doi: 10.2165/00002018-200730010-00008.
3
Smallpox vaccination and adverse reactions. Guidance for clinicians.天花疫苗接种与不良反应。临床医生指南。
MMWR Recomm Rep. 2003 Feb 21;52(RR-4):1-28.
4
Intensive hospital monitoring of adverse reactions to drugs.医院对药物不良反应进行强化监测。
Br Med J. 1969 Mar 1;1(5643):531-6. doi: 10.1136/bmj.1.5643.531.
5
Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in Italy.药物引起的神经精神反应：对意大利全科医生自发报告的分析。
Pharmacol Res. 2005 Mar;51(3):211-6. doi: 10.1016/j.phrs.2004.08.003.
6
[Damage to the digestive tract by some drugs. (Summary review)].[某些药物对消化道的损害。（综述摘要）]
Vnitr Lek. 1969 Mar;15(3):283-90.
7
Central nervous system side-effects of antihistamines in schoolchildren.
Rhinol Suppl. 1992 Sep;13:13-9.
8
[Patient reporting of adverse drug reactions in Norway 2010-13].
Tidsskr Nor Laegeforen. 2015 Mar 24;135(6):536-40. doi: 10.4045/tidsskr.14.1388.
9
Incidence of serious adverse drug reactions in general practice: a prospective study.全科医疗中严重药物不良反应的发生率：一项前瞻性研究。
Clin Pharmacol Ther. 2001 Jun;69(6):458-62. doi: 10.1067/mcp.2001.116145.
10
A survey of spontaneous reporting of adverse drug reactions in 10 years of activity in a pharmacovigilance centre in Portugal.葡萄牙一个药物警戒中心10年活动期间药品不良反应自发报告情况调查。
Int J Pharm Pract. 2014 Aug;22(4):275-82. doi: 10.1111/ijpp.12078. Epub 2013 Nov 5.
引用本文的文献
1
Detection of adverse drug events in e-prescribing and administrative health data: a validation study.电子处方和行政健康数据中不良药物事件的检测：一项验证研究。
BMC Health Serv Res. 2021 Apr 23;21(1):376. doi: 10.1186/s12913-021-06346-y.
2
Barriers to reporting of adverse drugs reactions: a cross sectional study among community pharmacists in United Kingdom.药品不良反应报告的障碍：一项针对英国社区药剂师的横断面研究。
Pharm Pract (Granada). 2017 Jul-Sep;15(3):931. doi: 10.18549/PharmPract.2017.03.931. Epub 2017 Aug 8.
3
Adverse drug reactions in children--a systematic review.儿童药物不良反应——系统评价。
PLoS One. 2012;7(3):e24061. doi: 10.1371/journal.pone.0024061. Epub 2012 Mar 5.
4
Effect of adverse drug reactions on length of stay in intensive care units.药物不良反应对重症监护病房住院时间的影响。
Clin Drug Investig. 1998;15(4):353-60. doi: 10.2165/00044011-199815040-00011.
5
Desire for information about drugs: relationships with patients' characteristics and adverse effects.
Pharm World Sci. 2002 Oct;24(5):205-10. doi: 10.1023/a:1020542502118.
6
Using computerized data to identify adverse drug events in outpatients.利用计算机化数据识别门诊患者的药物不良事件。
J Am Med Inform Assoc. 2001 May-Jun;8(3):254-66. doi: 10.1136/jamia.2001.0080254.
7
Consultations owing to adverse drug reactions in a single practice.单一医疗机构中因药物不良反应导致的会诊。
Br J Gen Pract. 2001 Feb;51(463):130-1.
8
Presenting clinical pharmacology and therapeutics: general introduction.临床药理学与治疗学概论：总论
Br J Clin Pharmacol. 1993 Jun;35(6):577-9. doi: 10.1111/j.1365-2125.1993.tb04184.x.
9
The impact of patient adherence on health outcomes for patients with chronic disease in the Medical Outcomes Study.医学结果研究中患者依从性对慢性病患者健康结局的影响。
J Behav Med. 1994 Aug;17(4):347-60. doi: 10.1007/BF01858007.
10
Towards the safer use of medicines.迈向更安全的用药方式。
BMJ. 1995 Oct 14;311(7011):1003-6. doi: 10.1136/bmj.311.7011.1003.
本文引用的文献
1
EPIDEMIOLOGICAL STUDIES OF ADVERSE DRUG REACTIONS.药物不良反应的流行病学研究
Am J Public Health Nations Health. 1965 Aug;55(8):1170-5. doi: 10.2105/ajph.55.8.1170.
2
TO-DAY'S DRUGS. SIDE-EFFECTS.今日药物。副作用。
Br Med J. 1965 May 1;1(5443):1174-6. doi: 10.1136/bmj.1.5443.1174.
3
ANGINA PECTORIS AND ARRHYTHMIAS DOCUMENTED BY CARDIAC TELEMETRY.通过心脏遥测记录的心绞痛和心律失常。
JAMA. 1964 Oct 12;190:115-8. doi: 10.1001/jama.1964.03070150025005.
4
PRE-EXISTING CONDITIONS, PLACEBO REACTIONS, AND "SIDE EFFECTS".既有病症、安慰剂反应及“副作用”。
Ann Intern Med. 1964 Feb;60:255-65. doi: 10.7326/0003-4819-60-2-255.
5
Adverse drug reactions during hospitalization.住院期间的药物不良反应。
Can Med Assoc J. 1967 Dec 9;97(24):1450-7.
6
Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility.药物不良反应的流行病学研究。V. 影响易感性的临床因素。
Ann Intern Med. 1966 Oct;65(4):629-40. doi: 10.7326/0003-4819-65-4-629.
7
Intensive hospital monitoring of adverse reactions to drugs.医院对药物不良反应进行强化监测。
Br Med J. 1969 Mar 1;1(5643):531-6. doi: 10.1136/bmj.1.5643.531.
8
Adverse nondrug reactions.药物不良反应。
N Engl J Med. 1968 Sep 26;279(13):678-9. doi: 10.1056/NEJM196809262791304.
9
Adverse drug reactions: a pharmacist-based monitoring system.药品不良反应：基于药剂师的监测系统
Clin Pharmacol Ther. 1970 Nov-Dec;11(6):802-7. doi: 10.1002/cpt1970116802.
10
A pharmacist-based study of the epidemiology of adverse drug reactions in pediatric medicine patients.
Am J Hosp Pharm. 1973 Oct;30(10):898-903.
Zotero 插件