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本文引用的文献

1
Serotypes of avian pleuropneumonia-like organisms.
Am J Vet Res. 1960 Mar;21:274-80.
2
Characterization of pleuropneumonia-like organisms of avian origin. I. Antigenic analysis of seven strains and their comparative pathogenicity for birds.禽源类胸膜肺炎微生物的特性。I. 七株菌株的抗原分析及其对禽类的比较致病性。
J Infect Dis. 1958 Mar-Apr;102(2):143-52. doi: 10.1093/infdis/102.2.143.
3
Antibiotic resistance in Mycoplasma isolates from tissue cultures.来自组织培养物的支原体分离株中的抗生素耐药性
Appl Microbiol. 1967 Jul;15(4):970. doi: 10.1128/am.15.4.970-.1967.
4
Antibiotic control of Mycoplasma in tissue culture.组织培养中支原体的抗生素控制
Appl Microbiol. 1967 Jan;15(1):82-5. doi: 10.1128/am.15.1.82-85.1967.
5
Combined antibiotic action: some definitions and correlations between laboratory and clinical results.联合抗生素作用：实验室结果与临床结果之间的一些定义及相关性
Antimicrob Agents Chemother (Bethesda). 1967;7:203-9. doi: 10.1128/AAC.7.2.203.
6
Effect of lincomycin and spectinomycin on airsacculitis of turkey poults.林可霉素和壮观霉素对雏火鸡气囊炎的影响。
Avian Dis. 1969 Nov;13(4):721-8.
7
Effect of lincomycin and spectinomycin water medication on chickens experimentally infected with Mycoplasma gallisepticum and Escherichia coli.林可霉素和壮观霉素饮水给药对实验性感染鸡毒支原体和大肠杆菌的鸡的影响。
Poult Sci. 1969 Sep;48(5):1703-8. doi: 10.3382/ps.0481703.

林可霉素和壮观霉素对禽支原体血清型的体外活性。

In vitro activity of lincomycin and spectinomycin against serotypes of avian mycoplasma.

作者信息

Hamdy A H, Blanchard C J

出版信息

Appl Microbiol. 1970 Jul;20(1):26-30. doi: 10.1128/am.20.1.26-30.1970.

DOI:10.1128/am.20.1.26-30.1970
PMID:4248002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC376860/
Abstract

Twenty strains of avian mycoplasma, representing 12 serotypes, were tested in vitro for their susceptibility to the action of lincomycin and spectinomycin alone and in combination. They varied in their sensitivity pattern. The ranges of minimal inhibitory concentration were 1 to 20 mug/ml for lincomycin or spectinomycin alone and 0.5/1 to 3/6 mug/ml for the lincomycin and spectinomycin combination. The ranges of minimal lethal concentration were greater with either single antibiotic than with the antibiotic combination. The amount of each antibiotic required to achieve mycoplasmacidal action of the relatively resistant strains was less with the antibiotic combination than with the single antibiotics.

摘要

对代表12种血清型的20株禽支原体菌株进行了体外试验，以检测它们对林可霉素和壮观霉素单独作用及联合作用的敏感性。它们的敏感模式各不相同。林可霉素或壮观霉素单独使用时的最低抑菌浓度范围为1至20微克/毫升，林可霉素和壮观霉素联合使用时为0.5/1至3/6微克/毫升。单一抗生素的最低致死浓度范围比抗生素联合使用时更大。对于相对耐药的菌株，实现支原体杀灭作用所需的每种抗生素的量，联合使用时比单一使用抗生素时要少。