Perlman D, Rahman S B, Semar J B
Appl Microbiol. 1967 Jan;15(1):82-5. doi: 10.1128/am.15.1.82-85.1967.
Seven of eight strains of Mycoplasma (PPLO) were found to be sensitive to the deoxystreptamines, certain macrolides, and the tetracyclines. These antibiotics are relative noncytotoxic. Kanamycin and tetracycline were useful in eliminating PPLO (pleuropneumonia-like organisms) strain Squibb no. 1 from a HeLa cell line which was deliberately contaminated with PPLO. Repeated exposure of M. laidlawii type B cells to neomycin resulted in a 50-fold increase in resistance, and the resistant strain was also resistant to gentamicin, kanamycin, neomycin, and paromomycin. A tetracycline-resistant strain of this culture was found to be resistant to 7-chlortetracycline, 7-chlor-6-demethyltetracycline, and 5-hydroxytetracycline. One PPLO strain, Squibb no. 2, derived from a contaminated HeLa cell culture, was resistant to all antibiotics studied.
八种支原体（类胸膜肺炎微生物）菌株中的七种被发现对脱氧链胺类、某些大环内酯类抗生素以及四环素敏感。这些抗生素相对无细胞毒性。卡那霉素和四环素可有效清除故意被类胸膜肺炎微生物菌株斯奎布1号污染的HeLa细胞系中的该菌株。将莱氏无胆甾原体B型细胞反复暴露于新霉素中会导致其耐药性增加50倍，且耐药菌株对庆大霉素、卡那霉素、新霉素和巴龙霉素也具有抗性。该培养物中的一株四环素耐药菌株对7-氯四环素、7-氯-6-去甲基四环素和5-羟基四环素也具有抗性。从受污染的HeLa细胞培养物中分离出的一株类胸膜肺炎微生物菌株斯奎布2号，对所研究的所有抗生素均具有抗性。
