四氧嘧啶处理大鼠的C14-脯氨酸代谢
C14-proline metabolism in alloxan treated rats.
作者信息
Brown R G, Liddy E P
出版信息
Can J Comp Med. 1970 Jul;34(3):265-8.
Abstract
The metabolism of C(14) proline was studied for a brief incorporation period during the early phases of alloxan treatment. The study showed that 150 gm alloxan-diabetic rats excreted a large quantity of prolyl rich peptides in the urine which is indicative of a failure in hydroxylation in the diabetic animals. The data from the skin confirmed this. Possible explanations were presented.
摘要
在四氧嘧啶治疗的早期阶段，对C(14)脯氨酸的代谢进行了短期掺入期研究。研究表明，150克四氧嘧啶诱导糖尿病的大鼠尿中排泄出大量富含脯氨酰的肽，这表明糖尿病动物存在羟基化功能障碍。皮肤实验数据证实了这一点。文中给出了可能的解释。
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引用本文的文献
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Influence of streptozotocin and alloxan induced diabetes on the metabolism of dermal collagen in albino rats.链脲佐菌素和四氧嘧啶诱导的糖尿病对白化大鼠皮肤胶原蛋白代谢的影响。
Acta Diabetol Lat. 1981 Jul-Sep;18(3):251-8. doi: 10.1007/BF02047897.
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