Modrak J
Diabetes. 1980 Jul;29(7):547-50. doi: 10.2337/diab.29.7.547.
The effect of diabetes on myocardial collagen metabolism was investigated in rats. Diabetes was induced by an i.v. injection of streptozotocin (60 mg/kg). The animals were killed after 3, 6, 18, or 26 wk of diabetes. Urinary glucose levels were measured by Tes-Tape. The myocardium was quickly removed and homogenized. Collagen was estimated by hydroxyproline content. Collagen synthesis was measured by 14C-proline incorporation. Myocardial collagen concentration and collagen synthesis was not altered in the diabetic rats. Collagen concentration did appear to increase in the 18- and 26-wk rats, but this was probably an age-related phenomenon. These results suggest that diabetes does not alter collagen metabolism in rats.
研究了糖尿病对大鼠心肌胶原代谢的影响。通过静脉注射链脲佐菌素（60毫克/千克）诱导大鼠患糖尿病。糖尿病3周、6周、18周或26周后处死动物。用尿糖试纸测量尿葡萄糖水平。迅速取出心肌并匀浆。通过羟脯氨酸含量估算胶原。通过14C-脯氨酸掺入法测量胶原合成。糖尿病大鼠的心肌胶原浓度和胶原合成未发生改变。在18周和26周的大鼠中胶原浓度似乎增加了，但这可能是一种与年龄相关的现象。这些结果表明糖尿病不会改变大鼠的胶原代谢。
