肌动蛋白和肌球蛋白的生物活性及3-甲基组氨酸含量
Biological activity and the 3-methylhistidine content of actin and myosin.
作者信息
Johnson P, Perry S V
出版信息
Biochem J. 1970 Sep;119(2):293-8. doi: 10.1042/bj1190293.
Abstract
- The 3-methylhistidine content of myosin varies according to muscle type. It is highest in myosin from white skeletal muscle and lower values are obtained from myosin of red skeletal and smooth muscle. 2. The 3-methylhistidine content of actin was similar in all of the types of muscle from which it was isolated. 3. The 3-methylhistidine of rabbit actin is localized in a single tryptic peptide that was readily modified during fractionation procedures. 4. Photo-oxidation studies indicated that the 3-methylhistidine residues are not essential for adeonsine triphosphatase and actin-combining activities of myosin. 5. During photooxidation G-actin lost completely the ability to polymerize to the F form before all the 3-methylhistidine was destroyed.
摘要
- 肌球蛋白的3-甲基组氨酸含量因肌肉类型而异。白色骨骼肌中的肌球蛋白含量最高，而红色骨骼肌和平滑肌中的肌球蛋白含量较低。2. 从所有分离出肌动蛋白的肌肉类型中，肌动蛋白的3-甲基组氨酸含量相似。3. 兔肌动蛋白的3-甲基组氨酸位于一个单一的胰蛋白酶肽段中，该肽段在分级分离过程中很容易被修饰。4. 光氧化研究表明，3-甲基组氨酸残基对于肌球蛋白的腺苷三磷酸酶和肌动蛋白结合活性并非必不可少。5. 在光氧化过程中，在所有3-甲基组氨酸被破坏之前，G-肌动蛋白完全丧失了聚合成F型的能力。
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